Oral care preparations comprising chlorhexidine and arginine or their salts

A technology for oral care and chlorhexidine, which is applied in the field of chlorhexidine or its salts, can solve the problems of product efficacy reduction, undesirable degradation products, etc., and achieve the effect of improving chemical stability

Pending Publication Date: 2021-08-06
梅达公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Such degradation is clearly undesirable as the efficacy of the product would be reduced and undesirable degradation products would be formed in the product for human ingestion

Method used

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  • Oral care preparations comprising chlorhexidine and arginine or their salts
  • Oral care preparations comprising chlorhexidine and arginine or their salts
  • Oral care preparations comprising chlorhexidine and arginine or their salts

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0167] Example 1: Efficacy of Combination (Background Example)

[0168] In vitro experiments were performed to test the efficacy of zinc acetate and chlorhexidine to inhibit the formation of volatile sulfur compounds (VSC).

[0169] Add 10 µl of the following solution to a freshly collected 1 ml sample of human saliva in a test tube:

[0170] 0.3% zinc acetate (1);

[0171] 0.025% chlorhexidine (2); and

[0172] - 0.025% Chlorhexidine + 0.3% Zinc Acetate (3).

[0173] The tubes were closed with stoppers and incubated overnight at 37°C. Tubes containing only saliva were used as controls. The gaseous VSC produced by the samples was measured by gas chromatography and compared with pure samples of hydrogen sulfide and methyl mercaptan.

[0174] combination HS FIC index MM FIC index control >27 000 000 >41 000 000 1 150 000 4 000 000 2 443 000 355 000 3 82 000 0.33 34 000 0.01

[0175] The composition comprising o...

Embodiment 2

[0181] Example 2: Exemplary Formulations

[0182] An example of a mouthwash according to the invention is as follows (formulation 1)

[0183]

[0184]

[0185] It should be understood that the compositions described above are examples only, and that the present invention is not limited to only such compositions.

Embodiment 3

[0186] Example 3: Stability Study

[0187] These studies used the following simplified formulations:

[0188]

[0189] The stability of the formulations was measured by HPLC-UV after storage at 60°C for 42 days. These formulations are stored in PET bottles with PP caps.

[0190] Compositions 1-4 included arginine as a stabilizer. Compositions 5-11 did not include arginine. In particular, compositions 1-4 and compositions 5-7 differ only in the presence or absence of arginine. The data indicate that arginine increases the stability of chlorhexidine.

[0191]

[0192]

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PUM

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Abstract

The invention relates to a liquid oral care composition that is a mouthwash, mouthrinse or a spray comprising: - 0.005 to 1% w / w chlorhexidine or a salt thereof; - arginine or a salt thereof; and - a zincsalt. The invention also relates to the use of arginineor a salt thereof for stabilising chlorhexidine or a salt thereof in a liquid oral care compositionthat is amouthwash, mouthrinse or a spray.

Description

technical field [0001] The present invention relates to a liquid oral care composition, which is a mouthwash, mouthwash or spray, comprising chlorhexidine or a salt thereof effective in preventing or alleviating symptoms associated with halitosis. Background technique [0002] Oral hygiene is an important consideration in the daily lives of children and adults worldwide. Maintaining good oral hygiene is essential to keep your mouth, teeth and gums disease-free and to prevent the growth of bacteria that can lead to the development of bad breath (bad breath). [0003] Bacteria located in the periodontal pockets and at the back of the tongue break down sulfur-containing amino acids, particularly cysteine ​​and methionine, to produce volatile sulfur compounds, including hydrogen sulfide and methyl mercaptan. [0004] These volatile sulfur compounds have an extremely unpleasant odor, even at low concentrations, and can penetrate epithelial cells and cause damage to the cells of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/36A61K8/43A61K8/44A61Q11/00
CPCA61K8/27A61K8/43A61K8/44A61Q11/00A61K2800/52A61K8/361A61K31/155A61K31/198A61K2300/00
Inventor E·菲利比A·扎那尔迪E·盖尔菲
Owner 梅达公司
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