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Nanofibrillated-cellulose-paper-based microfluidic devices

A microfluidic device and nanofibrillation technology, which is applied in chemical instruments and methods, instruments, laboratory utensils, etc., can solve the problems of solvent evaporation and slowness, and achieve the effect of broadening applications

Pending Publication Date: 2021-08-06
JIANGSU JICUI MICRO NANO AUTOMATION SYST & EQUIP TECH RES INST CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are some limitations in using paper as an analytical platform: the slow liquid flow rate in the channels of ordinary porous paper leads to severe solvent evaporation problems
[0004] However, conventional paper is usually not optically transparent, and this problem limits some microfluidic applications that require light transmission and / or light emission (e.g. absorption spectroscopy, fluorescence or electrochemiluminescence-ECL)

Method used

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  • Nanofibrillated-cellulose-paper-based microfluidic devices

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Embodiment Construction

[0051] The present invention will be further described in detail with reference to the drawings and examples. It should be noted that the following examples are for illustration purposes only, but not intended to limit the scope of the present invention.

[0052] experimental method:

[0053] Reagents and materials: (2,2,6,6-Tetramethylpiperidin-1-yl)oxynitride (TEMPO)-cellulose microfibrils (slurry, 0.3-1.0% solids) courtesy of University of Maine Supplied by Process Development Center. Ethylene vinyl acetate (EVA) films were obtained from Tianjin Caida New Material Co., Ltd. (Tianjin, China). Gold(III) chloride trihydrate (HAuCl4>99%), rhodamine B (RhB>95%), 4-(2-hydroxyethyl)piperazine-1-ethanesulfonic acid, N-(2-hydroxy Ethyl)piperazine-N'-(2-ethanesulfonic acid) (HEPES >99.5%) and phosphate-buffered saline (PBS, 10×) were purchased from Sigma-Aldrich (St. Louis, MO, USA). The solution was diluted with deionized water (18.2 MΩ·cm, Milli-Q gradient system, millipore). ...

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Abstract

The present invention provides a nanofibrillated-cellulose-paper-based microfluidic device comprising a transparent hollow channel fluidly connecting a fluid inlet to a fluid outlet, the transparent hollow channel comprise a fluid flow path defined by a floor, two or more side walls, and a ceiling, the floor comprises a transparent nanofibrillated cellulose paper, and the ceiling comprises a transparent NFC paper. The device is pump-free and broadening the application of paper-based microfluidics.

Description

technical field [0001] The present invention relates to the field of microfluidic devices for detecting analytes in fluids, and more particularly to a pumpless, transparent paper-based microfluidic device. Background technique [0002] Herein, nanofibrillated cellulose (NFC) paper (or nanopaper for short) was used as a substrate to facilely fabricate highly transparent hollow-channel nanopaper-based analytical devices (nanoPADs). Two rapid detection devices based on this design were developed: one for surface-enhanced Raman scattering (SERS) detection and the other for colorimetric detection. [0003] Paper has been widely used as a material for microfluidic analysis devices since the Whitesides group first reported a photolithographically patterned paper based platform for implementing multiplexed bioassays. Compared to polydimethylsiloxane (PDMS) or plastic-based microfluidic devices, paper-based microfluidics are low-cost, technically simple, and biodegradable. Another ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00G01N35/00
CPCB01L3/502707B01L2300/0816B01L2300/126
Inventor 应斌斌刘新宇
Owner JIANGSU JICUI MICRO NANO AUTOMATION SYST & EQUIP TECH RES INST CO LTD