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Traditional Chinese medicine composition with anti-cancer effect and anti-cancer traditional Chinese medicine implant

A composition and implant technology, applied in the field of anti-cancer traditional Chinese medicine implants, can solve the problems of low inhibition rate of lung cancer cell proliferation, unstable drug release rate of implants, etc., and achieve good anti-cancer effect and good inhibitory effect , the effect of inhibiting proliferation

Active Publication Date: 2021-08-10
HEILONGJIANG UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to solve the problem that the existing traditional Chinese medicine composition has a low inhibition rate on the proliferation of lung cancer cells and the drug release rate of the implant is unstable, and provides a Chinese medicine composition with anticancer effect and anticancer Chinese medicine Implants

Method used

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  • Traditional Chinese medicine composition with anti-cancer effect and anti-cancer traditional Chinese medicine implant

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specific Embodiment approach 1

[0027] Specific embodiment 1: The traditional Chinese medicine composition with anticancer effect in this embodiment is composed of Chinese medicine extract, Atractylodes lactone I and crocin, and the mass ratio of Chinese medicine extract, Atractylodes lactone I and crocin is 4 :1:(8~10);

[0028] The preparation method of described Chinese medicine extract is carried out according to the following steps:

[0029] 1. Weigh 2 to 10 parts of pinellia, 3 to 8 parts of gua lou, 10 to 20 parts of tangerine peel, 3 to 12 parts of scallion, 5 to 15 parts of berberine, 6 to 10 parts of Tinglizi and 3 parts by weight. ~8 parts of Baiying as raw material;

[0030] 2. Pulverize and mix the raw materials weighed in step 1 to obtain a mixture;

[0031] 3. Add distilled water and cellulase to the mixture, and perform ultrasonic enzymolysis to obtain an enzymatic solution;

[0032] 4. Add absolute ethanol to the enzymolysis solution, then let it stand at room temperature, and filter to o...

specific Embodiment approach 2

[0038] Embodiment 2: The difference between this embodiment and Embodiment 1 is that the traditional Chinese medicine composition with anticancer effect is composed of Chinese medicine extract, Atractylodes lactone I and crocin, and the Chinese medicine extract, Atractylodes lactone I and crocin The mass ratio of crocin is 4:1:8.

specific Embodiment approach 3

[0039] Specific embodiment three: the difference between this embodiment and specific embodiment one or two is that: the traditional Chinese medicine composition with anticancer effect is composed of traditional Chinese medicine extract, Atractylodes lactone I and crocin, and the traditional Chinese medicine extract, Atractylodes lactone I The mass ratio of Ⅰ and crocin is 4:1:10.

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Abstract

The invention discloses a traditional Chinese medicine composition with an anti-cancer effect and an anti-cancer traditional Chinese medicine implant, and relates to a traditional Chinese medicine composition and an implant. The problems that an existing traditional Chinese medicine composition is low in lung cancer cell proliferation inhibition rate and unstable in implant release rate are solved. The traditional Chinese medicine composition is prepared from a traditional Chinese medicine extract, atractylenolide I and crocin. The preparation of the implant comprises the steps: dissolving the PLGA and the mannitol in an organic solvent, adding the traditional Chinese medicine composition, performing drying, performing forming, performing sub-packaging and performing sterilizing. The auxiliary release device containing the anti-cancer traditional Chinese medicine implant is composed of a medicine storage bin, foamed plastic, the flaky anti-cancer traditional Chinese medicine implant and a mesh, the traditional Chinese medicine composition can inhibit proliferation of tumor cells and has low toxic and side effects, and the auxiliary release device ensures that the release rate is constant.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition with anticancer effect and an anticancer traditional Chinese medicine implant. Background technique [0002] Primary bronchial lung cancer, referred to as lung cancer, is a malignant tumor originating from the bronchial mucosa or glands. In recent years, the incidence and mortality of lung cancer have increased rapidly. Lung cancer is divided into non-small cell lung cancer and small cell lung cancer according to histopathology. Among them, non-small cell lung cancer accounts for 80% to 85% of the total number of lung cancers, including squamous cell carcinoma, adenocarcinoma, large cell carcinoma, adenosquamous carcinoma, and carcinoid. There are many ways to treat lung cancer. Although the diagnosis and treatment of lung cancer have made new progress, due to tumor metastasis and multidrug resistance, the prognosis of lung cancer patients is still poor, and the five-year survival ra...

Claims

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Application Information

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IPC IPC(8): A61K36/8962A61K9/20A61K47/34A61K47/10A61P35/00A61K31/7024A61K31/365
CPCA61K36/8888A61K36/428A61K36/752A61K36/8962A61K36/718A61K36/31A61K36/81A61K31/365A61K31/7024A61K9/0024A61K9/204A61K9/2018A61P35/00A61K2236/19A61K2236/33A61K2300/00
Inventor 袁瑶薇刘洋王晓慧邵琪
Owner HEILONGJIANG UNIV OF CHINESE MEDICINE
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