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A traditional Chinese medicine fermented preparation for treating gout and preparation method thereof

The technology of fermentation preparation and traditional Chinese medicine is applied in the field of traditional Chinese medicine fermentation preparation for treating gout and its preparation, which can solve the problems of increasing process steps and costs, complicated operation steps and the like, and achieves the effects of good probiotic effect, simple operation and enhanced drug efficacy.

Active Publication Date: 2022-04-29
北京羲太一中医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the operation steps of these three extraction methods are relatively cumbersome, and many process steps and costs have been added virtually. Therefore, it is extremely important to find a high-efficiency extraction of traditional Chinese medicine and a preparation process of traditional Chinese medicine preparations that can effectively treat gout.

Method used

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  • A traditional Chinese medicine fermented preparation for treating gout and preparation method thereof
  • A traditional Chinese medicine fermented preparation for treating gout and preparation method thereof
  • A traditional Chinese medicine fermented preparation for treating gout and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1 Chinese medicine superfine pulverization and conventional pulverization contrast

[0026] With the turmeric of the same batch as the test object, adopt the traditional Chinese medicine superfine pulverizer and the ordinary pulverizer (60-100 mesh) to carry out pulverization respectively and detect the curcumin content after pulverizing, the detection method adopts the curcumin detection method in the turmeric of Pharmacopoeia, utilizes Curcumin content detection by high performance liquid chromatography. The test result data shows that the average curcumin content of ultrafine pulverized turmeric is 3.19%, while the average curcumin content of ordinary pulverized turmeric is 2.05%, with a difference of 1.14%. The cell wall breaking rate of medicinal materials is higher, and the active ingredients in medicinal materials can be dissolved and released more easily.

Embodiment 2

[0027] Embodiment 2 Chinese medicine formula optimization

[0028] Using Chi Cang Teng 20g / L, Turmeric 20g / L, Licorice 20g / L, and Astragalus 20g / L as the optimized formula, and dandelion, barley, and tangerine peel as substitutes for traditional Chinese medicines, and then optimized the dosage of Chinese medicines to screen out the best treatment for gout. Compatibility and dosage of traditional Chinese medicine. Concrete Chinese medicine compatibility is as shown in Table 1, wherein, combination 1-combination 13 is the best Chinese medicine compatibility for screening treatment of gout, and implementation combination 1-implementation combination 9 is the optimal dosage for screening the best Chinese medicine compatibility for treatment of gout. Weigh the raw materials required for each combination according to 400L and add them to a 500L fermenter, add 400L of water, turn on the motor to stir at 80r / min, start to sterilize and cook at 100°C for 30min, set the inlet air temper...

Embodiment 3

[0033] Example 3 Selection of bacterial strains for traditional Chinese medicine fermentation and optimization of strain inoculum ratio

[0034] (1) Screening of strains resistant to traditional Chinese medicine: using 40g / L of A. chinensis, 20g / L of turmeric, 20g / L of licorice, 30g / L of barley, 30g / L of glucose, 8g / L of beef extract, 20g / L of agar, To screen the solid medium for the tolerance of traditional Chinese medicine, sterilize it at 100°C for 30 minutes, pour it into a plate, and cool it for later use. The bacterial strains used for the test were respectively inserted, and cultured anaerobically at 36°C for 48 hours, and observed whether there were colonies growing.

[0035](2) Degradation and screening of uric acid strains: Uric acid is the only nitrogen source, uric acid 1.0g / L, glucose 10g / L, sodium chloride 5g / L, magnesium sulfate 0.5g / L, dipotassium hydrogen phosphate 2g / L, Potassium dihydrogen phosphate 0.5g / L, agar 20g / L, is a uric acid solid medium, sterilize...

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Abstract

The invention provides a fermented traditional Chinese medicine preparation for treating gout and a preparation method thereof. Four traditional Chinese medicines, namely, cantaloupe, turmeric, licorice and coix seed, glucose and beef extract are used. Fermentation, the obtained traditional Chinese medicine fermentation liquid is spray-dried, and the collected dry powder is directly made into powder packaging or made into any one of capsules, tablets, and granules. The preparation method of the invention is simple to operate, can make full use of traditional Chinese medicinal materials and their active ingredients, and can effectively reduce blood uric acid through the synergistic effect of traditional Chinese medicine and probiotics, thereby achieving the effect of preventing or treating gout.

Description

technical field [0001] The invention belongs to the technical field of compound traditional Chinese medicines, and in particular relates to a fermented traditional Chinese medicine preparation for treating gout and a preparation method thereof. Background technique [0002] Gout is a disease directly caused by urate deposition. Long-term intake of high-purine foods, such as meat, animal offal, shellfish and other seafood, will lead to excessive intake of purine, which will lead to active purine metabolism. It can be broken down into uric acid by the body and cause hyperuricemia. Long-term hyperuricemia can cause urate deposition in joints and surrounding soft tissues, and then recurrent acute joint and soft tissue inflammation, tophi deposition, chronic arthritis and joint damage. Hyperuricemia can also involve the kidneys, causing chronic interstitial nephritis and urate stone formation. Early active uric acid-lowering treatment for gout patients can delay or prevent orga...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61P19/06A61K35/747A61K36/064
CPCA61K36/185A61K36/9066A61K36/484A61K36/8994A61K35/747A61K36/064A61P19/06A61K2236/19A61K2300/00
Inventor 林雪玉林松泉
Owner 北京羲太一中医药科技有限公司
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