Three-dimensional engineering breast cancer lung metastasis model, construction method and application

A technology of metastasis model and construction method, which is applied in the fields of biochemical equipment and methods, tumor/cancer cell, compound screening, etc., to achieve good application prospects and improve accuracy.
CN113278587AActive Publication Date: 2021-08-20WEIFANG MEDICAL UNIV
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Patent Information

Authority / Receiving Office
CN Β· China
Current Assignee / Owner
WEIFANG MEDICAL UNIV
Publication Date
2021-08-20

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Abstract

The invention relates to the field of tumor tissue engineering materials, and discloses a construction method of a three-dimensional engineering breast cancer lung metastasis model. The construction method includes construction of a primary diffuse leptomeningeal melanomatosis (PDLM)-collagen-chitosan scaffold, construction of a 3D breast cancer lung metastasis model of a single cell-composite scaffold, construction of a 3D breast cancer lung metastasis model of a multi-cell-composite scaffold and construction of a 3D breast cancer lung metastasis model of a multi-cell-composite scaffold-cytokine co-culture system. The invention further discloses the three-dimensional engineering breast cancer lung metastasis model and application. The model scaffold constructed by the invention is closer to components, mechanical strength and biochemical information of a lung extracellular matrix (ECM), the composite scaffold-based multi-cell co-culture system can better simulate a breast cancer lung metastasis microenvironment, constructed engineered tumor tissue is similar to biological characteristics of an in-vivo lung metastasis focus, and the model scaffold has important application value and prospect in research on the occurrence and development mechanism of breast cancer lung metastasis and an anti-tumor strategy.
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Description

technical field

[0001] The invention relates to the field of tumor tissue engineering materials, in particular to a three-dimensional engineered breast cancer lung metastasis model, a construction method and an application. Background technique

[0002] Breast cancer is the malignant tumor with the highest incidence rate in women, and has become the number one killer of women's health. The distant metastasis of breast cancer is considered to be the direct cause of the high mortality rate and recurrence rate of breast cancer. It is the most likely target organ for metastasis. 60-70% of breast cancer patients have lung metastases in the end. As one of the main reasons affecting the survival of breast cancer patients, lung metastasis has become extremely important to study its occurrence, development and related molecular mechanisms.

[0003] At present, it is extremely difficult to study lung metastasis of breast cancer in individual patients. In addition, there is a lack of ...

Claims

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