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An ureteral stent, methods and uses thereof

A polymer, matrix technology, applied in the field of ureteral stent, can solve the problems of uneven dissolution curve and fragmentation

Inactive Publication Date: 2021-08-31
ASSOC FOR THE ADVANCEMENT OF TISSUE ENG & CELL BASED TECH & THERAPIES A4TEC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The problem with these alginate-based scaffolds is the fact that it exhibits an uneven dissolution profile and fragmentation, resulting in the need for a secondary procedure to remove the fragments in some patients

Method used

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  • An ureteral stent, methods and uses thereof
  • An ureteral stent, methods and uses thereof
  • An ureteral stent, methods and uses thereof

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Embodiment Construction

[0075] Materials and methods

[0076] Materials - In one embodiment, sodium alginate, gelatin, urea, type IX urease from Canavalia ensiformis (Jack Bean), calcium chloride, chloroform, ethanol, bismuth(III) subcarbonate, disodium phosphate and Sodium azide was purchased from Sigma-Aldrich (Germany). Potassium dihydrogen phosphate orthophosphate and magnesium chloride hexahydrate were obtained from Riedel-de Haen (Germany).

[0077] Bismuth standards for ICP were obtained from Sigma-Aldrich (Germany). Polycaprolactone resin PCL 787, commercially available as TONE™ polymer, was obtained from Union Carbide Chemicals and Plastics Division, Bound Brook, New Jersey. Carbon dioxide (99.998 mol%) was supplied by Air Liquide (Portugal). All reagents were used as received without any further purification.

[0078] Preparation of the second-generation biodegradable ureteral stent - In one embodiment, polymers were dissolved in hot distilled water (70° C.) at different concentrations ...

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Abstract

The invention relates to an ureteral stent, methods and uses thereof. The present disclosure relates to ureteral stents, in particular a composition for ureteral stents that are used to ensure patency of a channel, namely the ureter which may be compromised, for example, by a urinary stone, neoplasia or a surgical procedure The solution now disclosed relates to a composition for biodegradable stents, in particular to ureteral stents and method for obtain such stents. This disclosure overcomes the problems encountered in the available stents, in particular, ureteral stents, as it namely: avoids the need for a second surgery for stent removal; decreases the morbidity in patients submitted to a surgical procedure; decreases or eliminates the risk of infection after the implantation of the ureteral stent.

Description

[0001] This application is a divisional application of Chinese Patent Application No. 201680040009.2 entitled "A Ureteral Stent, Method and Use" with the filing date of May 17, 2016. technical field [0002] The present disclosure relates to ureteral stents, and more particularly to a composition for ureteral stents for ensuring the patency of passages (ie, ureters) that may be damaged, for example, by urolithiasis, neoplasia, or surgery. Background technique [0003] First-generation biodegradable ureteral stents based on polymers of natural origin are currently being developed, even though existing technologies (described in Barros AA, Rita A, Duarte C, Pires RA, Sampaio-Marques B, Ludovico P, Lima E, Mano JF, Reis RL.2015.Bioresorbable ureteral stents from natural originpolymers; J Biomed Mater Res Part B 2015:103B:608-617) has proved to be an interesting alternative to traditional scaffolds, however, it has been shown that the scaffolds are effective in porcine models Fa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/04A61L31/10A61L31/14A61L31/16A61L31/18A61F2/04
CPCA61L31/041A61L31/18A61L31/10A61L31/16A61L31/148A61F2/04A61L2300/404A61L2300/416A61L2300/408A61L2430/22A61L2300/41A61F2250/0067A61F2002/048C08L5/04C08L89/00A61L31/042A61L31/045A61F2240/001A61F2250/0096A61P29/00A61P31/04A61P31/12A61P35/00B29C45/0001B29C71/0009B29K2089/00B29L2031/753
Inventor 瑞·路易斯·贡卡尔韦斯·多斯·赖斯阿纳·雷塔·克鲁兹·杜阿尔特亚历山大·安东尼奥·安图内斯·巴罗斯埃斯特瓦奥·奥古斯托·罗德里格斯·德·利马卡洛斯·安德·里贝罗·奥利韦拉若热·曼努埃尔·努涅斯·科雷亚·平托
Owner ASSOC FOR THE ADVANCEMENT OF TISSUE ENG & CELL BASED TECH & THERAPIES A4TEC