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Carboxymethylated carrageenan-aluminum compound micro-hydrogel carrier

A technology of carboxymethylated carrageenan and compound, applied in the field of medical materials, can solve the problems of poor biodegradation, residue, long disintegration time, etc., and achieve the effect of reducing side effect time and side effect.

Inactive Publication Date: 2021-08-31
广州市尚信净化工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

IR dosage forms are in many cases unable to achieve effective therapeutic effects due to the long disintegration time of the solid dosage form
At present, the commonly used disintegrants are cellulose and cross-linked polyvinylpyrrolidone, but their biodegradation is poor, and there are some residues in the body.

Method used

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  • Carboxymethylated carrageenan-aluminum compound micro-hydrogel carrier
  • Carboxymethylated carrageenan-aluminum compound micro-hydrogel carrier
  • Carboxymethylated carrageenan-aluminum compound micro-hydrogel carrier

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Experimental program
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Effect test

preparation example Construction

[0021] Preparation of Carboxymethylated Carrageenan

[0022] The κ-carrageenan powder was hydrated at 85°C for 15 min and overnight at room temperature to form a hydrated κ-carrageenan with a concentration of 5% (w / v). React at 10°C for 2.5h, gradually heat to 80°C, stir for 2h, stop the reaction, wash with methanol / water (80 / 20, v / v), adjust to neutral with glacial acetic acid, filter out the product, wash with methanol, And dry at 30-40°C.

Embodiment 1

[0024] 25% (w / v) model drug diclofenac sodium was dissolved in 30mL carboxymethylated carrageenan aqueous solution, and the solution was squeezed into the concentration of 12, 14, 16, 18, 20% (w / v) (marked as 1-1, 1-2, 1-3, 1-4, 1-5) containing 100mL of five groups of basic aluminum chloride with different concentrations of 0.05% (w / v) Tween 80 solution, in which the basic aluminum chloride solution consists of AlCl 3 ·6H 2 O aqueous solution and 7% (w / v) ammonia water were reacted at 60-70°C, and the obtained droplets were incubated in the gel medium for 30min, and the micro-hydrogel particles were collected by filtration, and the excess was washed with distilled water. Surface salt or ion 2-3 times, air dry;

[0025] Carry out drug load rate (%) to above-mentioned five groups of samples, the complete release time of medicine is analyzed, and its measuring condition is as follows:

[0026] 1) Drug loading rate (%): Pulverize a known amount of micro-hydrogel particles (~10...

Embodiment 2

[0034] 25% (w / v) model drug diclofenac sodium was dissolved in 30mL carboxymethylated carrageenan aqueous solution, and the solution was squeezed into 18% (w / v) containing 0.05% ( w / v) in the basic aluminum chloride solution of 100mL of Tween 80 (1-4 of embodiment 1), wherein the basic aluminum chloride solution is made of AlCl 3 ·6H 2 O aqueous solution was reacted with 7% (w / v) ammonia water at 60-70°C, and the obtained droplets were incubated in the gel medium for 10, 20, 30, 40, 50, 60 min (denoted as 2- 1, 2-2, 2-3, 2-4, 2-5, 2-6), and collect micro-hydrogel particles by filtration, wash excess surface salt or ions with distilled water for 2 to 3 times, and air dry;

[0035] Carry out drug loading rate (%) to above-mentioned five groups of samples, the complete release time of medicine is analyzed, and its measuring condition is the same as embodiment 1, and the result obtained is shown in Table 2;

[0036] Table 2: Effect of droplet incubation time on drug loading rate...

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Abstract

The invention relates to a carboxymethylated carrageenan-aluminum compound micro-hydrogel carrier. The micro-hydrogel carrier is mainly prepared from modified kappa-carrageenan, hydroxyl on a kappa-carrageenan galactan chain is subjected to carboxymethyl derivatization modification, and micro-hydrogel particles are prepared in an alkaline aluminum chloride solution; and the composite micro-hydrogel carrier disclosed by the invention has a relatively high drug loading rate, the immediate release (IR) degree of the drug is improved, enough blood concentration is provided after oral administration, and the composite micro-hydrogel carrier can be used as a dosage form material of the drug needing to take effect quickly.

Description

technical field [0001] The invention belongs to the field of medical materials, in particular to a carboxymethylated carrageenan-aluminum composite micro-hydrogel carrier. [0002] technical background [0003] An immediate release (IR) dosage form refers to a dosage form in which the rate of drug release from the formulation or absorption of the drug is not significantly or intentionally delayed. IR dosage forms are in many cases unable to achieve effective therapeutic effects due to the long disintegration time of the solid dosage form. At present, the commonly used disintegrants are cellulose and cross-linked polyvinylpyrrolidone, but their biodegradation is poor, and there are some residues in the body. κ-carrageenan is a natural biomaterial with excellent gel properties. Its skeleton is mainly composed of sulfated galactose and 3,6-endether-D-galactose through α-1,3-glycosidic bonds and β-1 , 4-glucosidic linkages connected alternately, is a naturally occurring linear ...

Claims

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Application Information

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IPC IPC(8): C08B37/00C08J3/075C08L5/00A61K47/36A61K31/196
CPCC08J3/075C08B37/0042A61K47/36A61K31/196C08J2305/00
Inventor 林文浩
Owner 广州市尚信净化工程有限公司
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