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Micro-fluidic chip for high-throughput culture of brain organs

A technology of microfluidic chips and organoids, which is applied in the field of microfluidic chips for high-throughput culture of brain organoids, which can solve the problems of large differences in sample formation, inability to better simulate the brain development process, and central area necrosis.

Pending Publication Date: 2021-09-10
SHANGHAI JIAO TONG UNIV
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Problems solved by technology

[0005] To sum up, most of the existing brain organoid models are based on static culture. With the prolongation of culture time, the central area of ​​brain organoids is necrotic due to the lack of nutrients and oxygen, and the increase of necrotic areas makes Can not better simulate the development process of the brain
At the same time, the cost of the existing bioreactor is high, the demand for the amount of medium is high, and the sample composition varies greatly

Method used

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  • Micro-fluidic chip for high-throughput culture of brain organs
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Embodiment Construction

[0027] The following describes several preferred embodiments of the present invention with reference to the accompanying drawings, so as to make the technical content clearer and easier to understand. The present invention can be embodied in many different forms of embodiments, and the protection scope of the present invention is not limited to the embodiments mentioned herein.

[0028] In the drawings, components with the same structure are denoted by the same numerals, and components with similar structures or functions are denoted by similar numerals. The size and thickness of each component shown in the drawings are shown arbitrarily, and the present invention does not limit the size and thickness of each component. In order to make the illustration clearer, the thickness of parts is appropriately exaggerated in some places in the drawings.

[0029] Such as figure 1 Shown is a chip design diagram of a preferred embodiment of the present invention, including one inlet, ei...

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Abstract

The invention discloses a micro-fluidic chip for high-throughput culture of brain organs, and relates to the field of brain organ culture, the micro-fluidic chip comprises an inlet, eight parallel channels and eight outlets; the inlet is respectively connected with the eight parallel channels; the eight parallel channels are connected with the eight outlets in a one-to-one correspondence manner; and a plurality of columns are arranged in the middle of each parallel channel. According to the method, the brain organs can be cultured in a high-throughput, high-repeatability and long-term mode, real-time imaging of the brain organs can be achieved, the necrosis area of the brain organs is small, and the brain organs closer to reality are provided for research of brain development.

Description

technical field [0001] The invention relates to the field of brain organoid culture, in particular to a microfluidic chip for high-throughput culture of brain organoids. Background technique [0002] Human brain research has always been an important and difficult point in neuroscience research. Since 2013, the emergence of brain organoid models has swept the field of neuroscience. It quickly and economically simulates the process of human brain development in vitro with a high degree of reduction. Recently, it is mostly used in clinical human brain diseases. Model building studies and drug testing studies. However, due to the lack of growth of blood vessels and the lack of concentration gradient guidance of development-related cytokine polarization signals, the current brain organoid models have limited growth and maturation, and lack of tissue integrity and inter-regional topological continuity, making this The superiority of the model is limited, and the universality of s...

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Application Information

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IPC IPC(8): B01L3/00C12M3/00
CPCB01L3/5027C12M21/08C12M23/16B01L2200/10B01L2300/0861
Inventor 丁显廷阿依努尔·阿卜拉
Owner SHANGHAI JIAO TONG UNIV
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