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Cytisine orally disintegrating tablet and preparation method thereof

The technology of genistein and orally disintegrating tablets is applied in the directions of pharmaceutical formulations, medical preparations with inactive ingredients, medical preparations containing active ingredients, etc. The problem of low utilization

Pending Publication Date: 2021-09-24
BEIJING VENTUREPHARM BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to overcome the shortcomings of cytisine ordinary tablets, such as poor compliance for those with dysphagia, low bioavailability, and bitter taste, which are difficult to make oral preparations, the inventors of the present invention have selected cytisine which can effectively improve cytisine through a large number of experiments. The taste of cytisine provides a cytisine orally disintegrating tablet with faster dissolution, stable quality and strong patient compliance

Method used

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  • Cytisine orally disintegrating tablet and preparation method thereof
  • Cytisine orally disintegrating tablet and preparation method thereof
  • Cytisine orally disintegrating tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0006] A kind of cytisine orally disintegrating tablet is made of components comprising the following percentages by weight:

[0007]

[0008] A method for preparing the above-mentioned cytisine orally disintegrating tablets by wet granulation, comprising the steps of:

[0009] Grind cytisine and pass through a 200 mesh sieve, add excipients in the prescription amount, 20% purified water as a wetting agent, granulate with a 40 mesh sieve, dry with air blast at 40°C, dry the moisture to 1~3%, pass the dried granules through Sieve with 30 meshes, weigh, convert yield, add siliconized microcrystal (90), menthol, acesulfame potassium and magnesium stearate, Φ6 flat punched tablets, tablet weight 150 mg, hardness 20-40 N.

Embodiment 2

[0011] A kind of cytisine orally disintegrating tablet is made of components comprising the following percentages by weight:

[0012]

[0013] A method for preparing the above-mentioned cytisine orally disintegrating tablets by wet granulation, comprising the steps of:

[0014] Crush cytisine through a 200-mesh sieve, add excipients in the prescribed amount, 20% purified water as a wetting agent, granulate with a 30-mesh sieve, dry at 40°C with air blast, dry to 1-3% moisture, pass the dried granules through Sieve with 30 meshes, weigh, convert yield, add siliconized microcrystal (90), menthol, acesulfame potassium and magnesium stearate, Φ6 flat punched tablets, tablet weight 150 mg, hardness 20-40 N.

Embodiment 3

[0016] A kind of cytisine orally disintegrating tablet is made of components comprising the following percentages by weight:

[0017]

[0018] A method for preparing the above-mentioned cytisine orally disintegrating tablets by wet granulation, comprising the steps of:

[0019] Crush cytisine through a 200-mesh sieve, add excipients in the prescribed amount, 20% purified water as a wetting agent, granulate with a 30-mesh sieve, dry at 40°C with air blast, dry to 1-3% moisture, pass the dried granules through Sieve 30 meshes, weigh, convert yield, add silicified microcrystal (50), menthol, acesulfame potassium and magnesium stearate, Φ6 flat punched tablets, tablet weight 150 mg, hardness 20-40 N.

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Abstract

The invention relates to the technical field of medicines, in particular to a cytisine orally disintegrating tablet and a preparation method thereof, and is characterized in that the cytisine orally disintegrating tablet contains cytisine and also contains a filling agent, a disintegrating agent, a lubricating agent and a flavoring agent. In addition, the disclosed preparation method adopts wet granulation, the technical technology is stable and mature, the preparation technology is simple, and therefore, the preparation method is suitable for large-scale production. The cytisine orally disintegrating tablet provided by the invention has the advantages of a high disintegration speed, an excellent taste, no grit feeling, good compliance and the like.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, relates to a cytisine orally disintegrating tablet and a preparation method thereof, and is a novel smoking cessation medicine with remarkable curative effect. Background technique [0002] Cytisine is a class of alkaloids with a tricyclic structure of α-pyridone, and is mostly distributed in legumes and Berberidaceae plants. Clinically, cytisine can be used for intramuscular or intravenous injection to rescue reflex apnea, shock and neonatal asphyxia caused by surgery and various traumas. Some recent studies have shown that this type of alkaloid also has various biological activities such as anti-arrhythmia and anti-infection. In recent years, cytisine, as a smoking cessation drug with obvious curative effect, has attracted the attention of the international medical community. Contents of the invention [0003] The object of the present invention is to provide an orally disintegrat...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K47/38A61K47/26A61K31/439A61P9/06A61P25/34
CPCA61K9/2018A61K9/2054A61K9/0056A61K31/439A61P25/34A61P9/06
Inventor 董玉娇王宇杰
Owner BEIJING VENTUREPHARM BIOTECH
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