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Application of MOTS-c peptide and derivative thereof in preparation of medicine for treating gestational diabetes mellitus

A technology of peptide derivatives and therapeutic drugs, which is applied in the field of biomedicine to reduce blood sugar levels, protect structure and function damage, and enhance insulin sensitivity and glucose tolerance

Pending Publication Date: 2021-09-28
NANJING MATERNITY & CHILD HEALTH CARE HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no relevant report of MOTS-c in GDM disease. Our study firstly proved the effectiveness and safety of MOTS-c in the treatment of GDM, which laid the foundation for the clinical application of MOTS-c

Method used

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  • Application of MOTS-c peptide and derivative thereof in preparation of medicine for treating gestational diabetes mellitus
  • Application of MOTS-c peptide and derivative thereof in preparation of medicine for treating gestational diabetes mellitus
  • Application of MOTS-c peptide and derivative thereof in preparation of medicine for treating gestational diabetes mellitus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Effects of MOTS-c on blood glucose and insulin resistance in GDM mice

[0032] experimental method

[0033] C57BL / 6 mice aged 6-8 weeks were used as the research objects, and the experiment was carried out after one week of acclimatization in the SPF animal room. Male mice were fed with normal diet, and female mice were fed with high-fat diet (60% fat). After 4 weeks of continuous feeding, female: male mice were placed in a cage at a ratio of 2:1. Streptozotocin (STZ, 30 mg / kg) was injected intraperitoneally every 24 hours for 3 consecutive injections; the random blood glucose of the mice was measured on the 5th day of pregnancy, and those with random blood glucose ≥ 11.1 mmol / L were considered successful in modeling. The GDM model mice were randomly divided into GDM group and MOTS-c group. The MOTS-c group was injected intraperitoneally with 10 mg / kg MOTS-c solution (MOTS-c dissolved in normal saline) every day, and the normal pregnancy group (NP) and the GDM group we...

Embodiment 2

[0037] Effects of MOTS-c on insulin sensitivity and glucose tolerance in GDM mice

[0038] experimental method

[0039]C57BL / 6 mice aged 6-8 weeks were used as the research objects, and the experiment was carried out after one week of acclimatization in the SPF animal room. Male mice were fed with normal diet, and female mice were fed with high-fat diet (60% fat). After 4 weeks of continuous feeding, female: male mice were placed in a cage at a ratio of 2:1. Streptozotocin (STZ, 30 mg / kg) was injected intraperitoneally every 24 hours for 3 consecutive injections; the random blood glucose of the mice was measured on the 5th day of pregnancy, and those with random blood glucose ≥ 11.1 mmol / L were considered successful in modeling. The GDM model mice were randomly divided into GDM group and MOTS-c group. The MOTS-c group was injected intraperitoneally with 10 mg / kg MOTS-c solution (MOTS-c dissolved in normal saline) every day, and the normal pregnancy group (NP) and the GDM grou...

Embodiment 3

[0043] The effect of MOTS-c on the birth weight of offspring of GDM mice

[0044] experimental method

[0045] C57BL / 6 mice aged 6-8 weeks were used as the research objects, and the experiment was carried out after one week of acclimatization in the SPF animal room. Male mice were fed with normal diet, and female mice were fed with high-fat diet (60% fat). After 4 weeks of continuous feeding, female: male mice were placed in a cage at a ratio of 2:1. Streptozotocin (STZ, 30 mg / kg) was injected intraperitoneally every 24 hours for 3 consecutive injections; the random blood glucose of the mice was measured on the 5th day of pregnancy, and those with random blood glucose ≥ 11.1 mmol / L were considered successful in modeling. The GDM model mice were randomly divided into the GDM group and the MOTS-c group. The MOTS-c group was injected intraperitoneally with 10 mg / kg MOTS-c solution (MOTS-c, dissolved in normal saline) every day. The normal pregnancy group (NP) and the GDM group ...

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Abstract

The invention provides application of mitochondria-derived polypeptide MOTS-c and a derivative thereof in preparation of a medicine for treating gestational diabetes mellitus (GDM), and belongs to the technical field of biomedicine. The MOTS-c is highly conserved in humans, rodents and various mammals, and it is found that the plasma MOTS-c content of a GDM pregnant woman is obviously reduced; the MOTS-c treatment can reduce pregnancy blood glucose of GDM model mice, improve insulin resistance, improve glucose tolerance, reduce offspring birth weight, protect pancreas islet functions and maintain insulin secretion; and therefore, the mitochondria-derived polypeptide MOTS-c has the potential of preparing medicines for preventing and treating GDM and complications thereof.

Description

technical field [0001] The invention belongs to the technical field of biomedicine technology, and specifically relates to the application of MOTS-c peptide and its derivatives in the preparation of drugs for treating gestational diabetes. Background technique [0002] GDM refers to abnormal glucose metabolism that occurs or is discovered for the first time during pregnancy, and is one of the most common complications during pregnancy. At present, the average incidence of GDM in the world is about 17.8%, and it is increasing year by year. It has become a serious global public health problem. GDM not only can cause fetal macrosomia, shoulder dystocia, postpartum hemorrhage, neonatal asphyxia or death in the short term, but also significantly increases the risk of metabolic diseases such as type 2 diabetes and obesity in the long term, and has a significant "transgenerational effect" in clinical practice . According to epidemiological surveys, 70.0% of pregnant women with GD...

Claims

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Application Information

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IPC IPC(8): A61K38/10A61K47/64A61P3/10A61P15/00
CPCA61K38/10A61K47/64A61P3/10A61P15/00
Inventor 崔县伟刘岚殷亚东
Owner NANJING MATERNITY & CHILD HEALTH CARE HOSPITAL
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