Perfoliote knotweed herb extract, preparation method thereof and application of perfoliote knotweed herb extract in preparation of non-alcoholic fatty liver disease or obesity drug

A fatty liver disease and non-alcoholic technology, which is applied in the field of medicine, can solve the problems such as the absence of the extract of scorpion root, and achieve the effect of improving weight loss, improving non-alcoholic fatty liver disease, and improving the level of lipid peroxidation in the liver

Inactive Publication Date: 2021-10-08
SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, there is no report on the treatment of non-alcoholic fatty liver disease or obesity with the extract of the root of the present invention.

Method used

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  • Perfoliote knotweed herb extract, preparation method thereof and application of perfoliote knotweed herb extract in preparation of non-alcoholic fatty liver disease or obesity drug
  • Perfoliote knotweed herb extract, preparation method thereof and application of perfoliote knotweed herb extract in preparation of non-alcoholic fatty liver disease or obesity drug
  • Perfoliote knotweed herb extract, preparation method thereof and application of perfoliote knotweed herb extract in preparation of non-alcoholic fatty liver disease or obesity drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1 The preparation of the extract of Rhizoma quinquefolius of the present invention (1)

[0037] Soak 100g crude drug in water for 2 hours, add 10 times the volume of water to decoct twice, 60 minutes each time, combine the two extracts, use a rotary evaporator to concentrate and constant volume, freeze overnight at -80°C, and put it in a condensation drier Dry for 48h to obtain the crude extract.

Embodiment 2

[0038] Embodiment 2 The preparation of the extract of Rhizoma quinquefolius of the present invention (two)

[0039] Soak 100g crude drug in water for 1 hour, add 8 times the volume of water to decoct twice, 40 minutes each time, combine the two extracts, use a rotary evaporator to concentrate and constant volume, freeze overnight at -80°C, and put it in a condensation drier Dry in medium for 60h to obtain the crude extract.

Embodiment 3

[0040] Embodiment 3 The preparation of the extract of Rhizoma quinquefolius of the present invention (three)

[0041] Soak 100g crude drug in water for 3 hours, add 12 times the volume of water to decoct twice, each time for 80 minutes, combine the two extracts, use a rotary evaporator to concentrate and constant volume, freeze overnight at -80°C, and put it in a condensation drier Dry for 40 h to obtain the crude extract.

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Abstract

The invention relates to a perfoliote knotweed herb extract, a preparation method thereof and application of the perfoliote knotweed herb extract in preparation of a non-alcoholic fatty liver disease or obesity drug. The preparation method of the perfoliote knotweed herb extract comprises the steps that a perfoliote knotweed herb crude drug is soaked with water for 1.5-2.5h, water with the volume 8-12 times that of the perfoliote knotweed herb crude drug is added for decoction twice, each time of decoction lasts for 40-80min, two extracting solutions are combined, a rotary evaporator is used for concentration and volume metering, the mixture stays overnight in a refrigerator at the temperature of -80 DEG C, the mixture is put into a condensation dryer to be dried for 40-60h, and a crude extract is obtained. Experiments in a high-fat fed mouse shows that the perfoliote knotweed herb extract has the obvious effects of resisting non-alcoholic fatty liver and losing weight.

Description

technical field [0001] The invention relates to the field of medicines, in particular to an extract of S. chinensis and its preparation method and its application in the preparation of non-alcoholic fatty liver disease or obesity medicines. Background technique [0002] Non-alcoholic fatty liver disease (NAFLD) is a metabolic disorder, a clinical syndrome characterized by lipid accumulation in the liver and hepatocyte bullous steatosis caused by non-alcoholic factors, often accompanied by dyslipidemia, insulin resistance In severe cases, it can progress to non-alcoholic steatohepatitis, liver cirrhosis and liver cancer. According to the global epidemiological survey, the incidence rate of NAFLD in the world is 10%-30%, the average rate in Asian countries is 11%-16%, and the prevalence rate in my country is about 15%. The pathogenesis of NAFLD is very complex and involves multiple pathways, including insulin resistance, inflammation, lipotoxicity, fat metabolism disorder, ox...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/70A61P3/06A61P1/16A61P3/04
CPCA61K36/70A61P3/06A61P1/16A61P3/04A61K2236/331A61K2236/39
Inventor 高月求孔晓妮林佳成刘冠杰孙学华
Owner SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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