Noninvasive coronary artery microcirculation detection method based on myocardial perfusion

Abstract

The invention discloses a noninvasive coronary artery microcirculation detection method based on myocardial perfusion, which is characterized in that a diagnosis method which is based on a CT perfusion imaging technology and is used for safely, rapidly and effectively evaluating coronary artery microvascular functions is established through fluid mechanics, and a rapid and accurate noninvasive coronary artery microcirculation function evaluation method is established to diagnose and treat diseases and guide treatment strategies. In combination with the achievement of a team on CT-FFR research and development in recent years, the invention aims to establish a CT perfusion scanning-based coronary artery microcirculation function evaluation method CT-IMR, evaluate the diagnosis accuracy through clinical verification and develop a noninvasive method for accurately and quickly evaluating the coronary artery microcirculation function by virtue of CT iconography, so that clinical requirements are met. Compared with an existing method, the brand-new noninvasive IMR detection method has the advantages of being noninvasive, rapid, accurate, safe, economical and the like, and the noninvasive IMR detection method can detect cases with only coronary artery microangiopathy and can also detect cases with combined coronary artery great angiopathy.

Description

technical field [0001] The invention relates to the field of biomedical engineering, in particular to a noninvasive coronary microcirculation detection method based on myocardial perfusion. Background technique [0002] According to the 2018 "China Cardiovascular Disease Report", the prevalence and mortality of cardiovascular disease in my country continue to rise, and it has been listed as one of the leading causes of death for Chinese residents for many years. Among them, the mortality rate caused by coronary artery disease is close to Half. Coronary artery disease, including coronary heart disease (coronary atherosclerotic heart disease and coronary spasm disease) and coronary microvascular disease (coronary microvascular disease, CMVD), seriously threatens the health of the people, and the resulting cardiovascular events (including cardiac death, myocardial infarction, heart failure, etc.) Circulation has become one of the main goals of coronary heart disease treatment....

AI Technical Summary

Problems solved by technology

A 7.5-year follow-up study of 11,223 patients with stable angina pectoris in Europe in 2012 showed that nearly 1 / 3 of the male and 2 / 3 of the female patients had no obstructive coronary artery disease on coronary angiography at the time of admission. Major cardiovascular events and all-cause mortality were significantly higher in patients with normal coronary angiography and non-obstructive coronary artery lesions than in controls in women, and the researchers speculated that CMVD may be an important reason for the poor prognosis of these patients

But in fact, this "most effective" method is still unable to distinguish the changes in radioactive activity caused by coronary macrovascular disease or microvascular disease. Therefore, when using this method to evaluate coronary microvascular function in some patients with coronary macrovascular disease Very limited and cannot be diagnosed accurately

Moreover, the human body needs to ingest a certain amount of radioactive isotopes during the examination process, which often makes many patients daunting. In addition, the examination is expensive and time-consuming. It often takes several hours to complete an examination, which cannot meet the needs of a large number of patients in a limited time.

In the process of coronary angiography, the perfusion and clearance of the contrast agent in the myocardium can be roughly judged by visually observing the myocardial microcirculation, but it cannot be accurately measured, and the subjectivity is high, so the accuracy and accuracy of the diagnosis cannot be guaranteed. specificity

The coronary microcirculation resistance index (IMR) measured by the temperature dilution method through the pressure guide wire during coronary angiography is considered to be the gold standard for invasive detection of coronary microcirculation dysfunction, but this method is harmful to the human body. Certain trauma, and there is a risk of coronary complications during the examination, and it is expensive, and it is difficult for patients to accept repeated examinations within a certain period of time, so it is not suitable to use this method to evaluate the treatment effect and screen effective therapeutic drugs, so it is urgently needed A safe, effective, rapid and affordable non-invasive examination method for early diagnosis of coronary microvascular disease, to guide the selection of treatment options, and to screen effective therapeutic drugs

Images