Variable-temperature isolated organ mechanical perfusion system

Abstract

The invention relates to a variable-temperature isolated organ mechanical perfusion system which comprises an organ preservation module, an oxygenation module, a temperature control module and a perfusion module; an outlet of the perfusion module is communicated with a liquid inlet of the oxygenation module, and the perfusion module is used for injecting perfusion liquid into the oxygenation module; a liquid outlet of the oxygenation module is communicated with an inlet of the temperature control module, and the oxygenation module is used for increasing the oxygen content in the perfusate and introducing the perfusate with the increased oxygen content into the temperature control module; the outlet of the temperature control module is communicated with an inlet of the organ preservation module, and the temperature control module is used for controlling the temperature of perfusate; the outlet of the organ preservation module is communicated with the inlet of the perfusion module, and the organ preservation module is used for absorbing nutrients in the perfusate and outputting the absorbed perfusate. The temperature of the perfusate can be adjusted, different temperature requirements of different isolated organs on the perfusate are met, the preservation time of the isolated organs is prolonged, and the universality of the system is improved.

Description

technical field [0001] The present disclosure relates to the technical field of isolated organ preservation, in particular to a variable temperature mechanical perfusion system for isolated organs. Background technique [0002] Organ transplantation plays an important role in clinical treatment. In order to protect the organs to be transplanted from damage, the organs to be transplanted are usually stored in cold storage or mechanical perfusion at room temperature. Simple cold preservation is based on the principle of reducing metabolic rate and reducing oxygen demand for the preservation of organs to be transplanted. Simple cold storage is simple to operate and requires less protective devices, which can meet the basic preservation of organs to be transplanted. Normal temperature mechanical perfusion is perfusion with oxygenated blood, drugs and nutrients at normal temperature to maintain the physiological environment and cell physiological metabolism of the organ to be tr...

AI Technical Summary

Problems solved by technology

[0003] With the increasing number of marginal donors, simple cold storage or room temperature mechanical perfusion storage will cause certain damage to the transplanted organs, which will easily cause complications after organ transplantation and bring certain risks to the recipients.

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