Preparation method and application of refined ginseng-pilose antler component with anti-Alzheimer's disease activity
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A ginseng antler and active technology, which is applied in the field of preparation of refined components, can solve problems such as unsatisfactory effects, achieve obvious anti-Alzheimer's effect, clear preparation method, and ensure reliability
Pending Publication Date: 2021-10-15
CHANGCHUN UNIV OF CHINESE MEDICINE
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At present, medical scholars at home and abroad are constantly researching on anti-AD active ingredients from traditional Chinese medicine, but there is no research report on the use of ginseng and velvet medicine for the treatment of AD, and the existing marketed products for improving memory function are still not enough clinically. ideal
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Embodiment 1
[0026] Step 1. Take several dry and clean raw sun-dried ginseng, crush them all, pass through a 20-mesh sieve, and prepare coarse powder for later use; take an appropriate amount of dried velvet antler, crush them all, pass through a 20-mesh sieve, and prepare coarse powder for later use;
[0027] Step 2: Select 8 parts of dried ginseng and 4 parts of dried velvet crushed body, use 70% ethanol (volume ratio) 10 times the total mass of ginseng and velvet dried crushed body as the extraction solvent, and use the reflux extraction method to dry ginseng and velvet antler The pulverized body was extracted, and each extraction was 60 min, and the extraction was done twice. Filter the extract and combine the filtrates;
[0028] Step 3: Take the filtrate in step 2, conduct membrane separation on the filtrate with an ultrafiltration membrane bag with a molecular weight cut-off of 3kd, and concentrate to obtain refined components.
[0029] Test of ginseng antler medicine on the inhibit...
Embodiment 2
[0047] Embodiment 2: preparation method of refined components of ginseng herb pair (same as embodiment 1)
[0048] Step 1. Take some dry and clean raw sun-dried ginseng, crush them all, pass through a 20-mesh sieve, and make coarse powder for later use; take an appropriate amount of dried antler, crush them all, pass through a 20-mesh sieve, and make coarse powder for later use.
[0049] Step 2: Select 500 g of dried ginseng and 250 g of dried antler and 250 g of dried antler, and use 70% ethanol that is 10 times the total mass of ginseng and dried antler as an extraction solvent, and use the reflux extraction method to extract the dried and crushed ginseng and antler. Extract twice, 1 hour each.
[0050] Step 3: Filtrate the extract and combine the two filtrates; use a 3kd ultrafiltration membrane to perform ultrafiltration on the filtrate in an ultrafiltration centrifuge, recover the solution filtered through the ultrafiltration membrane, and evaporate to dryness to obtain a...
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Abstract
The invention relates to a preparation method and application of a refined ginseng-pilose antler component with anti-Alzheimer's disease activity, and belongs to the field of traditional Chinese medicine development. The method mainly comprises the following steps: extracting ginseng and pilose antler coarse powder containing an ethanol aqueous solution, collecting filtrate, and carrying out membrane separation on the filtrate to obtain the ginseng-pilose antler drug refined component against Alzheimer's disease. The refined component capable of resisting the Alzheimer's disease is separated from the ginseng and pilose antler medicine pair for the first time, the preparation method is clear, the Alzheimer's disease resisting effect is obvious, the reliability of the effect of traditional Chinese medicine is guaranteed, and a foundation is laid for extraction and separation of effective components of the traditional Chinese medicine. The ginseng and pilose antler are expected to be developed into food or health care products which take ginseng and pilose antler as raw materials and have wide treatment effect and commercial development value, and the method has a positive effect on promoting the development of medicines with local characteristics in northeast China.
Description
technical field [0001] The invention belongs to the field of research and development of traditional Chinese medicines, and in particular relates to a preparation method and application of refined components of ginseng antler medicine against Alzheimer's disease. Background technique [0002] Alzheimer's disease is a common degenerative disease of the central nervous system, which mainly affects the elderly over 65 years old, and is usually called primary senile dementia. Clinically, it often manifests as memory dysfunction, loss of cognitive function, language function decline, etc., which seriously affects people's life and health. At present, reports on the pathogenesis of AD include not only congenital genetic and physical damage, but also a variety of major pathological mechanisms, such as cholinergic loss, oxidative damage, and β-amyloid protein (β-amyloid protein, Aβ) deposition. And nerve cell damage, etc., and then lead to changes in cerebral cortex folds, neuron l...
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