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A combined preparation for treating chronic wounds and preparation method thereof

A technology of chronic wounds and preparations, which is applied in the field of combined preparations for the treatment of chronic wounds and its preparation, can solve the problems of few prospective data and support, and achieve significant effects, promotion effects, and anti-inflammatory effects

Active Publication Date: 2022-08-09
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The management of chronic wounds has been a difficult problem for scientific researchers. Although clinicians have a large number of topical treatments / antimicrobial agents and dressings, there are few prospective data to support it.

Method used

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  • A combined preparation for treating chronic wounds and preparation method thereof
  • A combined preparation for treating chronic wounds and preparation method thereof
  • A combined preparation for treating chronic wounds and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1 Preparation of Combination Formulations

[0033] (a) First, add 4 mL of Span 80 to 36 mL of liquid paraffin, then mix in a water bath at 55°C, and use it as an oil phase for later use;

[0034] (b) 5 mg of flavonoid glycosides and 5 mg of erythromycin were dissolved in 20 mL of chitosan solution (5 mg / mL), then the mixed chitosan solution was added to the above oil phase, and stirred at 680 rpm 3h;

[0035] (c) 5mL of sodium tripolyphosphate (2mg / mL) was slowly added to the above stirring liquid, and continued stirring for 0.5h to obtain a uniform mixed liquid;

[0036] (d) the obtained mixed liquid is washed 3 times with 3 times the volume of petroleum ether, centrifuged, and dried in vacuum to obtain drug-loaded nanoparticles;

[0037] (e) Dissolving the nanoparticles in the aqueous solution, and stirring with ultrasonic, the nano-hydrogel loaded with flavonoid glycosides and erythromycin can be obtained. According to the different ratios of flavonoid glyc...

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Abstract

The invention discloses a combined preparation for treating chronic wounds and a preparation method thereof, belonging to the technical field of bioengineering. The combined preparation of the present invention is divided into two preparations, A and B, A is a lotion; B is a spray, wherein the lotion A is Wangbuliuxing with chitosan nano-hydrogel loading 0.5%-2% Flavonoid glycosides and 0.5%-2% of Erythromycin, and the spray B is chitosan nano-hydrogel loaded with 3%-5% of Wangbuliu flavonoids and 3%-5% of Wangbuliuxing Do not leave the erythromycin solution. The combined preparation of the present invention has a significant anti-inflammatory effect on chronic wound sites, and has a significant promoting effect on angiogenesis at the wound site.

Description

technical field [0001] The invention relates to a combined preparation for treating chronic wounds and a preparation method thereof, belonging to the technical field of bioengineering. Background technique [0002] Chronic trauma not only leads to a decline in the quality of life of patients, but also imposes a huge economic burden on the patients' families. From a demographic point of view, the number of people with chronic trauma and healing disorders is reaching epidemic proportions, and the burden on human health and the economy will become heavier. Therefore, more and more researchers pay attention to the study of chronic trauma. The process of wound healing can be summarized as blood clot formation, inflammation, tissue regeneration and tissue remodeling. During the inflammatory phase, the early inflammatory response mobilizes local inflammatory factors and systemic defense responses to the wound site. The inflammatory phase of chronic wounds lasts a long time. The...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/722A61K31/437A61K31/7048A61K9/06A61K47/02A61K47/06A61K47/36A61P17/02A61P31/04
CPCA61K31/722A61K31/7048A61K31/437A61K9/06A61K47/02A61K47/06A61K47/36A61P17/02A61P31/04A61K2300/00Y02A50/30
Inventor 侯豹戚梦婷朱雪锐于晓依班雅婷胡江涛康心勉蔡维维邱丽颖
Owner JIANGNAN UNIV
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