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Coding type nano-robot and control and preparation method thereof

A technology of nanomachines and control methods, applied in biochemical equipment and methods, nanotechnology, nanotechnology, etc., can solve the problems of low experimental success rate, jumping, and short capture time, and achieve the effect of reducing temperature drift

Active Publication Date: 2021-11-02
SOUTHEAST UNIV
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Problems solved by technology

[0006] In terms of nanopore research, currently in the capture of DNA by nanopores, due to the existence of mechanical and temperature drift, whether using atomic force microscopy, optical tweezers, or magnetic tweezers, the time it takes for molecules to be captured in nanopores Shorter, most of them will jump, resulting in low success rate of experiments

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  • Coding type nano-robot and control and preparation method thereof
  • Coding type nano-robot and control and preparation method thereof

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Embodiment Construction

[0036] In order to deepen the understanding of the present invention, the present invention will be further described below in conjunction with the accompanying drawings. This embodiment is only used to explain the present invention, and does not constitute a limitation to the protection scope of the present invention.

[0037] Such as figure 1 As shown, the present invention includes nanorobots and nanorobot walking substrates suitable for nanorobots, wherein the nanorobot walking substrates include substrates 1, nanopores 2 and nanoelectrodes 5 arranged on nanopores 2; nanoelectrodes 5 and independent voltage The source is connected; the nanopore 2 runs through the substrate 1;

[0038] Nanorobots are composed of micro-nanoparticles 3 and two deoxyribose nucleic acid chains 4, the specific layout of which can be found in figure 1 shown. The base film 1 for the nano-robot to walk is processed with an array of nanoholes 2 and nano-gold electrodes 5 .

[0039] The ends of th...

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Abstract

The invention relates to a coding type nano-robot and a control and manufacturing method thereof. According to the coding type nano-robot and the control and manufacturing method thereof, the direction and the strength of a voltage source connected with a nano-pore and a nano-gold electrode can be adjusted through coding, then the electroosmotic flow strength in the nano-pore is controlled, therefore electroosmotic driving and electrophoresis driving are combined or competitive driving is utilized, and the motion direction and the motion speed of the coding type nano-robot with multiple degrees of freedom are accurately controlled, so that molecules to be tested can be quickly and effectively researched. The lengths of two desoxyribonucleic acid chains of the nano-robot can be adjusted, the nano-robot has a large-range adjustable measuring range, and the motion range of the coding type nano-robot under the capturing condition can be controlled by synthesizing the desoxyribonucleic acid chains with different tail end sulfhydrylation lengths based on the distance between the two nano-pores.

Description

technical field [0001] The invention relates to a combined driving technology of electroosmosis and electrophoresis based on nanopores; in particular, it relates to a coded nanometer machine and its control and preparation methods. Background technique [0002] Nanorobots are important molecular machines that can automate complex nanomechanical tasks. So far, the development of DNA nanorobots has been limited to simple functions, such as walking in a controlled direction, and the control process is very complicated and difficult to control. [0003] Since the control of nanorobots is a difficult and complex task, especially for nanorobots with slightly more complex functions, the control methods are more complicated. [0004] Professor Lulu Qian reported a nano-robot assembled from single-stranded DNA in the journal Science. The nano-robot can walk autonomously on the surface of a substrate covered with DNA origami, grab certain molecules, and release them to designated are...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B25J7/00B25J9/16B25J19/00C12N15/10B82Y30/00C23C16/40C23C16/455C23C14/35C23C14/10
CPCB25J7/00B25J9/1602B25J9/1656B25J19/007C12Q1/686B82Y30/00C23C16/402C23C16/45525C23C14/35C23C14/10C12Q2563/131C12Q2563/155
Inventor 司伟朱振东袁润逸沙菁陈云飞
Owner SOUTHEAST UNIV
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