The invention discloses an intelligent biological
eardrum based on individualized 3D printing and a preparation method thereof, and belongs to the technical field of
medical instruments, and the
eardrum comprises an individualized
eardrum substrate, a PEDOT: PSS flexible
electrode array integrated on the inner surface of the substrate, a multi-frequency bioelectrical impedance detection module, a VCT module and a
central processing unit. Through multi-frequency bioelectrical impedance detection and VCT imaging, an
auricle conductivity distribution map can be reconstructed, a nerve active area can be accurately identified, and personalized transcutaneous nerve electrical stimulation parameters can be generated. The invention further provides a corresponding intelligent nerve regulation and
control system, a preparation method and a parameter adjustment method based on physiological
signal feedback, an integrated solution from individualized manufacturing, precise recognition to self-adaptive closed-loop regulation and control is achieved, and the intelligent nerve regulation and
control system is particularly suitable for individualized nerve regulation and
control treatment of
irritable bowel syndrome and other diseases; the problems of low stimulation precision, lack of individuation, poor comfort, no closed-loop feedback and the like in the prior art are effectively solved.