Hollow fiber bioreactor for artificial liver

Abstract

The invention discloses a hollow fiber bioreactor of an artificial liver. The hollow fiber bioreactor comprises a round hose sleeving the outer sides of all hollow fiber tubes, and two ends of the round hose are fixedly connected with colloid sealing structures in a sealing manner; a circular cylinder is a reducing circular cylinder, the diameter of one end close to a blood distributor is small, the diameter of one end close to a blood outlet collector is large, a small-diameter cylinder and a large-diameter cylinder are in arc transition, and a nutrient solution inlet pipe penetrating through and fixedly sealed on the wall of the large-diameter cylinder communicates with the interior of the round hose; a nutrient solution outlet pipe which penetrates through and is fixedly sealed on the small-diameter cylinder wall communicates with the interior of the round hose; a fluid inlet is formed in the wall of the large-diameter cylinder, and a fluid outlet is formed in the wall of the small-diameter cylinder; and when fluid flows in from the fluid inlet and flows from the large-diameter cylinder to the small-diameter cylinder with a reduced cross section, the venturi effect occurs, toxins can penetrate through a hollow fiber membrane from the blood side to enter the nutrient solution side easily, the detoxification effect can be enhanced, efficient detoxification of the artificial liver is achieved, and the expected treatment effect is achieved.

Description

technical field [0001] The invention relates to the technical field of biomedical devices, in particular to a hollow fiber bioreactor for an artificial liver. Background technique [0002] Through an external mechanical or physical and chemical device, the artificial liver uses pressure to drive the patient's blood to flow through the external artificial liver system, and takes on the role of temporarily assisting or completely replacing the severely diseased liver, removing various harmful substances, and compensating for the metabolic function of the liver. The human body's own liver function is restored or liver transplantation is performed. [0003] The hollow fiber bioreactor is the part used to remove toxins in the artificial liver device, and is the core of the artificial liver device system. Hollow fiber bioreactors are generally composed of a number of hollow fiber tubes such as 5000-15000, cylindrical plexiglass tubes, blood inlet distributors, blood outlet collec...

AI Technical Summary

Problems solved by technology

It can be seen that the existing artificial liver relies entirely on the flow of blood and nutrient solution to generate a pressure difference, thereby achieving convective mass transfer and removing toxins. This method has a certain therapeutic effect, but because the pressure difference is not very large, the efficiency of detoxification is not high. High, unable to achieve the expected therapeutic effect

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