Preparation method of spraying hydrogel for treating solar dermatitis

A hydrogel and dermatitis technology, applied in the field of preparation of sprayed hydrogel, to achieve the effect of broad application prospects, convenient use, and comfortable body feeling

Active Publication Date: 2021-12-07
NORTHWEST UNIV(CN)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are few functional products in the market that can not only provide good sun protection for the affected skin but also have effective therapeutic effects

Method used

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  • Preparation method of spraying hydrogel for treating solar dermatitis
  • Preparation method of spraying hydrogel for treating solar dermatitis
  • Preparation method of spraying hydrogel for treating solar dermatitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1 Preparation of sprayable hydrogel

[0034] Step 1: Dissolve 6 g of p-hydroxyphenylpropionic acid, 4 g of N-hydroxysuccinimide and 4 g 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, then add 150mL concentration of 0.12g / mL gelatin aqueous solution, adjust its pH to 6 and stir for 12h, then The mixed solution was put into a dialysis bag with a molecular weight cut-off of 3500D and dialyzed with deionized water for 3 days, and the mother liquor obtained from the dialysis was freeze-dried to obtain a gelatin-p-hydroxyphenylpropionic acid copolymer. The copolymer was detected by FTIR and 1H NMR, and it was determined that p-hydroxyphenylpropionic acid was grafted to gelatin, such as figure 1 , 2 shown.

[0035] Step 2: Take 0.4g of gelatin-p-hydroxyphenylpropionic acid copolymer prepared in step 1 and 20mg of dexamethasone sodium phosphate and dissolve them in 10mL of aqueous solution in turn to obtain a gelatin-p-hydroxyphenylpropionic acid mix...

Embodiment 2

[0038] Example 2 Preparation of Sprayable Hydrogel

[0039]Step 1: Dissolve 6 g of p-hydroxyphenylpropionic acid, 3 g of N-hydroxysuccinimide and 3.5 g 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, then add 150mL concentration of 0.15g / mL aqueous gelatin solution, adjust its pH to 4.5 and stir for 10h, then The mixed solution was put into a dialysis bag with a molecular weight cut-off of 3500D and dialyzed with deionized water for 3 days, and the mother liquor obtained from the dialysis was freeze-dried to obtain a gelatin-p-hydroxyphenylpropionic acid copolymer.

[0040] Step 2: Take 1g of gelatin-p-hydroxyphenylpropionic acid copolymer prepared in step 1 and 10mg of dexamethasone sodium phosphate and dissolve them in 10mL aqueous solution in turn to obtain a gelatin-p-hydroxyphenylpropionic acid mixed solution with a concentration of 0.1g / mL , and then add 1 mL of horseradish peroxidase aqueous solution with an enzyme activity of 50 U / mL to obtain a sprayable...

Embodiment 3

[0043] Example 3 Preparation of Sprayable Hydrogel

[0044] Step 1: Dissolve 3 g of p-hydroxyphenylpropionic acid, 3 g of N-hydroxysuccinimide and 3 g 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, then add 150mL concentration of 0.1g / mL gelatin aqueous solution, adjust its pH to 4 and stir for 10h, then The mixed solution was put into a dialysis bag with a molecular weight cut-off of 3500D and dialyzed with deionized water for 3 days, and the mother liquor obtained from the dialysis was freeze-dried to obtain a gelatin-p-hydroxyphenylpropionic acid copolymer.

[0045] Step 2: 1g of gelatin-p-hydroxyphenylpropionic acid copolymer described in step 1 and 5mg of dexamethasone sodium phosphate were dissolved in 10mL aqueous solution successively to obtain gelatin-p-hydroxyphenylpropionic acid with a concentration of 0.1g / mL Mix the solution, and then add 0.3 mL of horseradish peroxidase aqueous solution with an enzyme activity of 50 U / mL to obtain a sprayable hydro...

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Abstract

The invention discloses a preparation method of a spraying hydrogel for treating solar dermatitis. The preparation method comprises the following steps of: preparing a gelatin-p-hydroxyphenylpropionic acid copolymer, a sprayable hydrogel liquid A and a sprayable hydrogel liquid B, and finally preparing the sprayable hydrogel. The spraying hydrogel prepared by the invention can realize ultraviolet radiation resistance, moisture retention, inflammation resistance and allergy resistance of the skin of an affected part, also can realize slow release and continuous transdermal absorption of an anti-inflammatory drug dexamethasone sodium phosphate, and can realize the effects of on-demand administration and timely drug stop for solar dermatitis. The coating of the spraying hydrogel can be well attached to the irregular skin surface of any patient, the thickness of the coating is controllable, toughness is high, peeling and cracking are avoided, the body feeling is comfortable, and the double effects of sunscreen and treatment on the skin of the patient can be effectively achieved.

Description

technical field [0001] The invention relates to a method for preparing a sprayed hydrogel for treating solar dermatitis, and belongs to the technical field of biomedical materials. Background technique [0002] The skin is the largest organ of the human body, accounting for about 8% of the human body mass, covering the entire exterior of the body, and is crucial to ensuring the normal physiological activities of the body. With the intensification of ozone layer destruction, the use of photosensitive substances and the abnormal immune system function caused by sub-health state, the number of patients with solar dermatitis is increasing every year. In patients with solar dermatitis, the skin of the affected area often presents with redness, swelling, burning, pain, and even symptoms such as blisters, burning pain, and skin desquamation. Some patients also have systemic symptoms such as headache, fever, nausea, and vomiting, and even severe dermatitis The patient's skin will b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/573A61K47/42A61P17/00A61P17/16C08H1/00A61K8/04A61K8/34A61K8/63A61K8/65A61K8/81A61Q17/04
CPCA61K9/06A61K47/42A61K31/573A61P17/16A61P17/00C08H1/00A61K8/65A61K8/63A61K8/8129A61K8/345A61K8/042A61Q17/04
Inventor 惠俊峰姚嘉玲姚嘉欣范代娣郑晓燕薛心雨
Owner NORTHWEST UNIV(CN)
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