New application of penicillin G sodium salt

A penicillin and new-purpose technology, applied in the application field of pharmaceutical compositions or preparations, can solve problems such as family and social economic burden, unsure of clinical efficacy, decreased working ability, etc., to improve blood supply, inhibit platelet aggregation, and prevent thrombosis. effect

Pending Publication Date: 2021-12-07
司正仕
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

③The 11th edition changed the name of the disease to rheumatoid arthritis, and believed that: "Rheumatoid arthritis (abbreviation) causes direct death is rare, mainly causes disability, makes life unable to take care of oneself, reduces work ability,

Method used

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  • New application of penicillin G sodium salt
  • New application of penicillin G sodium salt
  • New application of penicillin G sodium salt

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0024] Example 1

[0025] Patient Jiang Moumou, female, 61 years old, came to the clinic because of swelling and pain in fingers, toes and joints of limbs for more than 1 year, which aggravated for 1 month. The history of the present illness suggested that the patient had a sudden chill one day a year ago, and had a high fever of 39.6°C in the afternoon. After sweating profusely, he felt soreness and discomfort in his fingers and toes. The next day, he developed morning stiffness in his hands. The morning stiffness of the fingers disappeared, and after February, it aggravated to more than 1 hour a day, and the swelling and pain gradually increased in the fingers and toes, especially the swelling and pain of the metacarpophalangeal joints and proximal interphalangeal joints of both hands, which has lasted for more than half a year time. In the past 1 month, the condition has worsened, the swelling and pain have increased significantly, and a swelling has grown on the left toe,...

Example Embodiment

[0029] Example 2

[0030] Patient Yin Moumou, female, 61 years old, suffered from pain all over the body, especially in both knee joints. Physical examination on admission: listlessness, 5 mung bean-sized nodules were found on the back of both hands, hard and painless when pressed, all small joints of the hands were deformed: the proximal interphalangeal joints were fusiform and swollen, both wrists were radially oriented Lateral rotation, deviation, ulnar deviation of fingers and palms, severe flexion of proximal interphalangeal joints, hyperextension of distal interphalangeal joints showing "buttonhole flower" deformity and more than 4 groups, proximal interphalangeal joints of multiple fingers Changes in the shape of a "shuttle", with dislocation or subluxation of multiple toe joints, and the toes are basically arranged irregularly overlapping up and down, especially the knee joints are highly swollen, and the skin on the knees is almost cracked and translucent. The buckli...

Example Embodiment

[0036] Example 3

[0037] Patient Wang Moumou, female, 41 years old, did not dare to move for two years due to morning stiffness, swelling and pain of multiple joints in both hands, joint deformation of fingers, both wrists were unable to move due to severe pain, her hands were weak, and she could not even hold a job None, often dropped bowls and chopsticks, asked patients to help with cooking when hospitalized. The patient has great psychological pressure, poor appetite, and eats less and less food. He only eats half a meal per meal and does not eat vegetables. Before joining the hospital, he was diagnosed with rheumatoid arthritis many times in the local hospital.

[0038] Physical examination shows: middle-aged female, thin, poor nutrition, symmetrical index finger, middle finger and ring finger proximal knuckles of both hands are "spindle-shaped". The interval is vague, the patient has standard morning stiffness (the duration of morning stiffness is more than 60 minutes p...

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Abstract

The invention relates to the field of medicinal chemistry, in particular to application of penicillin G sodium salt in preparation of a pharmaceutical composition or a preparation for treating rheumatoid arthritis. The application of penicillin G sodium salt in preparation of the pharmaceutical composition or the preparation for treating rheumatoid arthritis is characterized in that the penicillin G sodium salt or a derivative thereof is used for preparing the pharmaceutical composition or the preparation for treating the rheumatoid arthritis. The pharmaceutical composition or the preparation for treating rheumatoid arthritis further contains vitamin C. The pharmaceutical composition or the preparation contains penicillin G sodium salt or a derivative thereof in an amount of 16,000,000-20,000,000 units per day. The pharmaceutical composition or the preparation has the advantages of high treatment speed, ultrahigh effective rate and higher cure rate (related to the number and the proportion of patients insisting to the end, as long as the illness state of some patients is controlled, the patients are satisfactory and stop continuous treatment, and the cure rate is invisibly influenced), the toxic and side effects are small, and safety and reliability.

Description

Technical field: [0001] The invention relates to the field of medicinal chemistry, in particular to the application of penicillin G sodium salt in the preparation of pharmaceutical compositions or preparations for treating rheumatoid arthritis. Background technique: [0002] Rheumatoid arthritis is a common disease both at home and abroad, almost seen in all races and nationalities, in most people, the incidence of rheumatoid arthritis is about 0.5% to 1.5%, but in some Indian tribes in the United States, rheumatoid arthritis The incidence rate of arthritis is as high as 3.5%~5.3% (Jiang Lindi, Mei Zhenwu-Practical Internal Medicine 11th Edition Chapter Four, Rheumatoid Arthritis). The disease has a long course of disease and cannot be cured for a long time. It not only leads to poverty, but also can cause complications of multiple organ damage, which seriously threatens the health and life safety of patients. It has become one of the key research diseases in rheumatology de...

Claims

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Application Information

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IPC IPC(8): A61K31/43A61K9/08A61K9/72A61P19/02A61P37/02A61K31/375
CPCA61K31/43A61K31/375A61K9/0019A61K9/0078A61P19/02A61P37/02A61K2300/00
Inventor 司正仕
Owner 司正仕
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