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Establishment method of radix ophiopogonis decoction material reference

A method of establishment, the technology of Maimendong Decoction, applied in the field of establishment of material benchmarks of Maimendong Decoction, can solve the problem of small prescription dose, treatment effect needs to be compared and tested, prescription prescription, dosage, preparation method and administration method do not match, etc. problem, to achieve clear spots, reduce inspection costs, and improve safety and stability

Pending Publication Date: 2021-12-07
GUANGDONG YIFANG PHARMA
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Problems solved by technology

[0003] However, the prescription dosage of Maimendongtang granule Chinese medicine sold in Japan is small, and its prescription, dosage, preparation method and administration method are not consistent with the records in ancient books, and the therapeutic effect needs to be compared and tested
In recent years, many domestic scholars have conducted studies on the pharmacology, pharmacodynamics and pharmacokinetics of the chemical components and effective components in Maimendong Decoction, mainly focusing on pharmacology research, and the substances in the decoction There are few studies on the basis, extraction process, multi-index component content determination and characteristic maps, and there is a lack of systematic research
And there are few studies on how to measure the consistency between the quality of large-scale production preparations and traditional decoctions

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Embodiment Construction

[0153] In order to make the purpose, technical solution and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the accompanying drawings and specific embodiments.

[0154] Maimendong decoction of the present invention comes from "Synopsis of the Golden Chamber" written by Zhang Zhongjing in the Han Dynasty based on ancient textual research in various aspects. The determined formula of Maimendong decoction is as follows: 130.55g of Maimendong, 18.65g of Pinellia radix, 7.46g of ginseng g, licorice 7.46g, japonica rice 5.60g, jujube 9.70g. The decoction pieces of each medicinal material have been identified as complying with the relevant provisions of the first part of the Pharmacopoeia of the 2020 edition. Because raw pinellia contains irritating and toxic ingredients, there may be problems of drug safety if it is not processed in a modern way. Combined with the licorice slices contained in Maimendong...

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Abstract

The invention discloses a method for establishing a radix ophiopogonis decoction substance reference. The method comprises the following steps: identifying radix ophiopogonis, ginseng, Chinese dates and liquorice by adopting a thin layer chromatography; constructing a characteristic spectrum to identify components in the radix ophiopogonis decoction; and determining the contents of methylophiopogon japonicus dihydrohomoisoflavone A, methylophiopogon japonicus dihydrohomoisoflavone B, liquiritin, glycyrrhizic acid, ginsenoside Rg1, ginsenoside Re and ginsenoside Rb1 in the radix ophiopogonis decoction. The method provided by the invention can comprehensively reflect the quality attribute of the traditional decoction of the radix ophiopogonis decoction, ensures the consistency of the quality of the radix ophiopogonis decoction preparation and the decoction, and comprehensively and effectively controls the product quality.

Description

technical field [0001] The invention relates to the technical field of quality analysis and detection of traditional Chinese medicines, in particular to a method for establishing material standards of Ophiopogon japonicus soup. Background technique [0002] Maimendong Decoction comes from the "Synopsis of the Golden Chamber" written by Zhang Zhongjing in the Han Dynasty: "Those who are against the upper air, have a bad throat, and stop the adverse air, the Maimendong soup is the main one. Maimendong seven liters, pinellia one liter, ginseng two liang , 2 liang of licorice, 3 pairs of japonica rice, 12 pieces of jujube. Add six flavors, take 1 bucket of water and 2 liters, boil 6 liters, serve warm for 1 liter, and take it once a day, three nights.” Modern times are often used to treat chronic bronchitis, bronchial Ecstasy, tuberculosis, silicosis, chronic pulmonary fibrosis, chronic pharyngitis, gastric and duodenal ulcers, chronic gastritis, diabetes and Sjogren's syndrome,...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/06G01N30/86G01N30/90
CPCG01N30/02G01N30/06G01N30/8679G01N30/90Y02A50/30
Inventor 吴晓纯罗文安朱德全陶晨璐范倩孙冬梅魏梅程学仁鲁云陈向东
Owner GUANGDONG YIFANG PHARMA
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