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Method for establishing radiation-induced lung injury rat animal model

A radiation-induced lung injury and animal model technology, applied in animal husbandry and other fields, can solve the problem of lack of uniform and accurate standards for animal models, and achieve the effects of meeting the needs of animal experiments, good reproducibility, and avoiding excessive damage

Pending Publication Date: 2021-12-10
CHINA INST FOR RADIATION PROTECTION
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Problems solved by technology

[0004] In addition, seeking efficient, cheap, and low-toxic radiation protection methods is also the focus of research by experts at home and abroad, but there is a lack of uniform and accurate standards for the establishment of animal models

Method used

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  • Method for establishing radiation-induced lung injury rat animal model
  • Method for establishing radiation-induced lung injury rat animal model
  • Method for establishing radiation-induced lung injury rat animal model

Examples

Experimental program
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Embodiment 1

[0020] Example 1: Establishment of an animal model of radiation-induced lung injury in rats

[0021] (1) Experimental animals and grouping

[0022] 32 healthy male SPF grade SD rats were purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd. (production license number: SCXK (Beijing) 2016-0006), weighing 160-180g. According to the body weight of the animals, they were randomly divided into 0Gy irradiation group (control group) and 20Gy irradiation group, with 16 animals in each group. Rats were housed in separate cages, 4 in each cage, free to eat and drink, and the feed was SPF mouse maintenance feed produced by Beijing Keaoxieli Feed Co., Ltd. The temperature of the breeding room is controlled at 20-25°C, and the humidity is controlled at 40-70%. Rat breeding cages and drinking water bottles are regularly disinfected, and the bedding used is all autoclaved. After grouping, the rats were marked with picric acid. Experiments were carried out after the...

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Abstract

The invention belongs to the technical field of animal model construction, and relates to a method for establishing a radiation-induced lung injury rat animal model. According to the method, the lung of a rat is irradiated by using an electronic line to establish the radiation-induced lung injury rat animal model. By means of the method for establishing the radiation-induced lung injury rat animal model, the radiation-induced lung injury rat animal model can be established in a short period, high accuracy and good reproducibility, excessive injury to the rats in the modeling process due to different doses and irradiation modes is avoided, and the established animal model can better meet the requirements of animal experiments.

Description

technical field [0001] The invention belongs to the technical field of animal model construction, and relates to a method for establishing a radiation-induced lung injury rat animal model. Background technique [0002] The National Cancer Statistics Report in 2020 pointed out that the incidence of tumors in the chest region such as lung cancer (17.9%) and breast cancer (9.1%) has long been at the forefront. As one of the main treatment methods for tumor patients, radiotherapy has a significant effect on killing tumor cells and inhibiting tumor growth. However, radiotherapy will cause damage to normal tissue cells in the irradiation field while killing tumor cells. Among them, radiation lung injury is the most common cause of chest tumor The most common complication of radiotherapy seriously affects the effect of radiotherapy and postoperative recovery. [0003] Radiation-induced lung injury is a non-infectious inflammation with two stages of acute radiation pneumonitis and ...

Claims

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Application Information

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IPC IPC(8): A01K67/027
CPCA01K67/027A01K2207/35A01K2227/105A01K2267/03
Inventor 王远飞李曙芳王新钢许文黎黄立群王永丽尹晶晶岳娟李梅张亚娟杨彪
Owner CHINA INST FOR RADIATION PROTECTION
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