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Application of nicotinamide mononucleotide in pregnancy aiding and miscarriage prevention

A single nucleotide and nicotinamide technology, applied in the direction of application, medical preparations containing active ingredients, functions of food ingredients, etc., to achieve the effect of maintaining normal development, high safety, and rich variety

Pending Publication Date: 2021-12-31
武汉生命奥义生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no literature report on whether nicotinamide mononucleotide can promote pregnancy and miscarriage

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 2

[0028] Carry out tire protection effect test, the specific test method is as follows:

[0029] Select pregnant woman 60 examples of 4-12 weeks of gestation, be divided into experimental group 30 examples and matched group 30 examples at random, the experimental group begins to take the preparation of the present invention to prevent miscarriage treatment after blood examination HCG rises, and the control group routine miscarriage treatment;

[0030] The result shows that the success rate of fetal preservation in the experimental group is 93.3%, which is obviously higher than that in the control group (83.3%), which shows that the preparation of the present invention has a significant effect on repeated embryo stop development.

Embodiment 3

[0032] Animal experiments are carried out to test the effect of assisting pregnancy and preventing miscarriage. The specific test methods are as follows:

[0033] Select 60 bab / c female mice of 8-10 weeks old, and divide them randomly into an experimental group of 30 cases and a control group of 30 cases. The experimental group takes NMN 50 mg of this prescription for 1-2 consecutive months. Then the mice in the experimental group and the control group were caged separately. Observe the pregnancy rate, birth rate, and survival rate of pups;

[0034] The results showed that the pregnancy rate of the experimental group was 93.3%, the birth rate was 100%, and the survival rate of the pups was 90%. The pregnancy rate of the control group was 76.6%, the birth rate was 100%, and the survival rate of the pups was 80%. It shows that the present invention is beneficial to assist pregnancy and improve the survival rate of cubs.

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PUM

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Abstract

The invention relates to application of nicotinamide mononucleotide in pregnancy aiding and miscarriage prevention. The nicotinamide mononucleotide can be used as an active pharmaceutical ingredient and a pharmaceutically acceptable auxiliary material for preparation, and the mass percentage of the dosage is 1-1000mg / kg body weight / day. The nicotinamide mononucleotide has the advantage that animals or people can be assisted in pregnancy and miscarriage prevention.

Description

technical field [0001] The present invention relates to the application of nicotinamide mononucleotide, in particular to the application of nicotinamide mononucleotide in assisting pregnancy and preventing miscarriage. Background technique [0002] With the improvement of people's living standards, the opening of the two-child policy. Many women are now facing the situation of late marriage and late childbearing. However, after the age of 35, the body of women is in a downward trend, facing an increase in the incidence of infertility and fetal malformation. The possibility of fetal intrauterine growth retardation and premature delivery in advanced maternal age is greater, and the risk of complications in advanced maternal age increases. And other issues. [0003] Nicotinamide mononucleotide (NMN for short) is an endogenous substance existing in the body, which can be chemically synthesized in vitro. Current studies have found that it has the effect of delaying aging and r...

Claims

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Application Information

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IPC IPC(8): A61K31/706A61P15/06A23L33/125
CPCA61K31/706A61P15/06A23L33/125A23V2002/00A23V2200/30
Inventor 丰明乾朱元奎刘路
Owner 武汉生命奥义生物科技有限公司
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