Composite optical fiber for brain nerve detection and treatment and preparation method thereof

A composite optical fiber and nerve technology, applied in the fields of therapy, electrotherapy, light therapy, etc., to achieve the effect of powerful multifunctional characteristics

Pending Publication Date: 2022-01-07
GUILIN UNIV OF ELECTRONIC TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The existing mainstream neural regulation stimulation methods include drug / chemical regulation, electrical stimulation regulation, optogenetic regulation, ultrasonic regulation, magnetic stimulation regulation, etc. These treatment methods correspond to different therapeutic devices, and few medical devices can Combining two or more of these medical methods into the brain in a minimally invasive way for brain nerve detection and stimulation therapy

Method used

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  • Composite optical fiber for brain nerve detection and treatment and preparation method thereof
  • Composite optical fiber for brain nerve detection and treatment and preparation method thereof
  • Composite optical fiber for brain nerve detection and treatment and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Such as Figure 10 It is a multi-functional application of a single composite optical fiber for the measurement of brain nerve potential, photodynamic stimulation, and fixed-point drug delivery.

[0043] (1) The composite optical fiber pigtail is placed at the neuron to be tested in the brain through interventional surgery.

[0044](2) Through the silica capillary optical fiber 2 of the fan-in part 4 of the composite optical fiber, light-sensitive genes are perfused into the microhole 7-3 of the composite optical fiber, or reagents such as experimental drugs are injected. The light-sensitive gene is transferred to and expressed in the neurons of the relevant circuit through a specific promoter. Light-sensitive target genes include excitatory channel protein genes and inhibitory channel protein genes, wherein excitatory channel protein genes such as ChR2, ChETA, VChR1 or SFOs are medium, and inhibitory channel protein genes are such as NpHR, Arch or MAC.

[0045] (3) T...

Embodiment 2

[0048] Such as Figure 11 It is a multi-functional application of dual composite optical fibers for collaborative measurement of brain nerve potential, photodynamic stimulation, and fixed-point drug delivery.

[0049] (1) Two composite optical fiber pigtails are respectively placed in different positions of the same neuron to be tested in the brain through interventional surgery, or placed in two different positions of related neurons.

[0050] (2) Inject the light-sensitive gene into the microhole 7-3 of the first composite optical fiber 7a through the quartz capillary fiber 2 of the fan-in part 4 of the first composite optical fiber 7a, or inject reagents such as experimental drugs. The light-sensitive gene is transferred to and expressed in the neurons of the relevant circuit through a specific promoter. Light-sensitive target genes include excitatory channel protein genes and inhibitory channel protein genes, wherein excitatory channel protein genes such as ChR2, ChETA, V...

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Abstract

The invention provides a composite optical fiber for brain nerve detection and treatment. The composite optical fiber is characterized in that the composite optical fiber comprising a fan-in device and a composite optical fiber pigtail which are integrally prepared; the fan-in device comprises an optical fiber bundle gradient cone, a double-clad optical fiber, a quartz capillary optical fiber and an electric signal transmission channel; and the composite optical fiber pigtail comprises a micro-flow pore channel, an electric signal transmission channel, an optical waveguide fiber core, an electrode contact and an optical fiber cladding. The optical fiber bundle gradient cone is manufactured by selectively inserting the double-clad optical fiber and the quartz capillary optical fiber into a porous quartz sleeve and then performing integrated high-temperature pressure controlled tapering, the pigtail is lengthened to form the composite optical fiber, a liquid metal circuit is injected into the micropores of the composite optical fiber, and packaging is carried out by using solid metal to form an electrode contact. The composite optical fiber can be used for intracerebral nerve potential detection, drug administration treatment and optical information acquisition. The composite optical fiber can be widely applied to diagnosis and treatment of intracranial nervous system diseases.

Description

technical field [0001] The invention relates to a composite optical fiber used for brain nerve detection and treatment and a preparation method thereof, belonging to the technical field of optical fiber medical devices. Background technique [0002] Neuromodulation is the use of implantable and non-implantable technologies to change the activity of the central and peripheral nerves by physical or chemical methods, so as to achieve the regulatory effect of inhibiting or exciting the nervous system. Neurological disorders such as Alzheimer's disease have significant implications. For this reason, researchers are committed to continuously exploring precise and efficient regulation methods. [0003] The existing mainstream neural regulation stimulation methods include drug / chemical regulation, electrical stimulation regulation, optogenetic regulation, ultrasonic regulation, magnetic stimulation regulation, etc. These treatment methods correspond to different therapeutic devices...

Claims

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Application Information

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IPC IPC(8): G02B6/26G02B6/255A61M31/00A61B5/369A61N5/06A61N1/36C03B37/027C03B37/012
CPCG02B6/26G02B6/2552A61M31/00A61B5/369A61N5/0601A61N5/062A61N1/36103C03B37/027C03B37/01222
Inventor 苑立波杨世泰
Owner GUILIN UNIV OF ELECTRONIC TECH
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