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Rat intervertebral disc degeneration model construction method

A construction method and intervertebral disc technology, applied in the field of rat intervertebral disc degeneration model construction, to achieve the effect of low test cost

Inactive Publication Date: 2022-02-08
山东第一医科大学附属颈肩腰腿痛医院
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] However, the current methods of establishing intervertebral disc degeneration models are mostly focused on the intervertebral disc itself. For example, for the rupture of the intervertebral disc annulus fibrosus, there were surgically exposed cutting injury models or annulus fibrosus puncture models. With the development of technology, percutaneous puncture assisted by C-arm To reduce animal infection and death, there are direct suction models, enzyme dissolution models and inflammatory factor stimulation models for the nucleus pulposus, but they all ignore that as a member of the spinal joint connection system, it will be affected by other stable structures such as ligaments. Therefore, we propose a method for constructing a rat intervertebral disc degeneration model

Method used

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  • Rat intervertebral disc degeneration model construction method

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Effect test

Embodiment 1

[0025] see figure 1 , a rat intervertebral disc degeneration model construction method, comprising the following steps:

[0026] S1: Test preparation, select 20 healthy rats, set up the total modeling device according to the needs, and divide the total modeling device into D1 modeling area, D2 modeling area, D3 modeling area... DN making In the modeling area, multiple rats were placed in the modeling area, and each group of modeling areas was equipped with multiple sets of cameras and lounges.

[0027] S2: Rats degenerated, the rats were separated through the modeling area, and multiple groups of rats were taken out of the uninjured spinal motion segments (here, complete and undamaged refers to the ligaments and joints between the two vertebrae that constitute the motion segment) and the intervertebral disc are intact), the tensile mechanics test is carried out on the ligaments on the spinous process and between the spinous processes in the non-injured spinal motion segment, ...

Embodiment 2

[0037] see figure 1 , a rat intervertebral disc degeneration model construction method, comprising the following steps:

[0038] S1: Test preparation, select 20 healthy rats, set up the total modeling device according to the needs, and divide the total modeling device into D1 modeling area, D2 modeling area, D3 modeling area... DN making In the modeling area, multiple rats were placed in the modeling area, and each group of modeling areas was equipped with multiple sets of cameras and lounges.

[0039] S2: Rats degenerated, the rats were separated through the modeling area, and multiple groups of rats were taken out of the uninjured spinal motion segments (here, complete and undamaged refers to the ligaments and joints between the two vertebrae that constitute the motion segment) and the intervertebral disc are intact), the tensile mechanics test is carried out on the ligaments on the spinous process and between the spinous processes in the non-injured spinal motion segment, ...

Embodiment 3

[0049] see figure 1 , a rat intervertebral disc degeneration model construction method, comprising the following steps:

[0050] S1: Test preparation, select 20 healthy rats, set up the total modeling device according to the needs, and divide the total modeling device into D1 modeling area, D2 modeling area, D3 modeling area... DN making In the modeling area, multiple rats were placed in the modeling area, and each group of modeling areas was equipped with multiple sets of cameras and lounges.

[0051] S2: Rats degenerated, the rats were separated through the modeling area, and multiple groups of rats were taken out of the uninjured spinal motion segments (here, complete and undamaged refers to the ligaments and joints between the two vertebrae that constitute the motion segment) and the intervertebral disc are intact), the tensile mechanics test is carried out on the ligaments on the spinous process and between the spinous processes in the non-injured spinal motion segment, ...

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Abstract

The invention relates to the technical field of model construction, and discloses a rat intervertebral disc degeneration model construction method, which comprises the following steps: S1, test preparation; S2, rat degeneration; S3, rat modeling; and S4, rat degeneration comparison. According to the invention, different modeling data are obtained through a plurality of groups of rats according to different ages, weights and test durations, and are compared to obtain data of intervertebral disc degeneration, so that the influence of different weights, living environments and ages on the intervertebral disc is obtained, the data of the intervertebral disc of the human body is enriched, and a researcher can select a direction for checking the later human body intervertebral disc data test; and scoring is performed according to a rat intervertebral disc degeneration improvement scoring table, specific data of the rat intervertebral disc degeneration degree of a rat experimental group is analyzed, then painless treatment is performed on the rats after the experiment is completed, and virus-free treatment is performed on the dead bodies of the rats, so that the requirements on materials and machines are low.

Description

technical field [0001] The invention belongs to the technical field of model building, in particular to a method for building a rat intervertebral disc degeneration model. Background technique [0002] The intervertebral disc is divided into the nucleus pulposus in the central part, which is rich in elastic jelly-like substance; the fibrous ring in the peripheral part is arranged in concentric circles by multiple layers of fibrocartilage rings, the fibrous ring in the neck and waist is thicker in the front and thinner in the back, and the nucleus pulposus is easy to protrude posterolaterally , into the spinal canal or intervertebral foramen, compression of the spinal cord or spinal nerves - disc herniation. A herniated disc can be rehabilitated using aerobics. [0003] However, the current methods of establishing intervertebral disc degeneration models are mostly focused on the intervertebral disc itself. For example, for the rupture of the intervertebral disc annulus fibro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61D1/00A61B5/00
CPCA61D1/00A61B5/4566A61B5/0077A61B2503/40A61B2503/42
Inventor 曹盛楠陈元振侯广建王丹丹师彬孙国栋谢良玉许文昌刘文波
Owner 山东第一医科大学附属颈肩腰腿痛医院