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Application of ovarian cancer cells in preparation of medicine for treating pancreatic cancer

A technology for ovarian cancer cells and pancreatic cancer, applied in the field of biomedicine, can solve the problems of poor chemotherapy effect of pancreatic cancer, unsatisfactory prognosis, diagnosis and treatment prognosis, and patient survival rate of less than 20%.

Inactive Publication Date: 2022-02-08
北京箭牧科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, the only curative method for pancreatic cancer is surgical resection, but the five-year survival rate of patients undergoing surgery is less than 20%, so finding better forms of treatment and treatment options has become an urgent problem to be solved for pancreatic cancer
Although gemcitabine is used as a first-line drug in the chemotherapy of pancreatic cancer, due to the existence of primary and acquired drug resistance, only a part of pancreatic cancer patients are sensitive to gemcitabine; therefore, the chemotherapy effect of pancreatic cancer is not good. , treatment to prognosis is not satisfactory

Method used

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  • Application of ovarian cancer cells in preparation of medicine for treating pancreatic cancer
  • Application of ovarian cancer cells in preparation of medicine for treating pancreatic cancer
  • Application of ovarian cancer cells in preparation of medicine for treating pancreatic cancer

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Embodiment Construction

[0021] The present invention will be further described in detail below in conjunction with the embodiments and the accompanying drawings, but the embodiments of the present invention are not limited thereto.

[0022] 1. Experimental materials

[0023] 1. Experimental cells

[0024] Human ovarian cancer SKOV3 cells, human pancreatic cancer SW1990 cells.

[0025] 2. Experimental animals

[0026] BALB / c nude mice, 16-18g, SPF grade, male, were purchased from Beijing Huafukang Animal Experiment Co., Ltd.

[0027] 3. Main reagents

[0028] 3.1 Positive control drug: gemcitabine, manufactured by Eli Lilly and Company.

[0029] 3.2 Reagents: sterile saline, RPMI1640 medium, fetal bovine serum.

[0030] 2. Experimental method

[0031] 1. Cell culture conditions:

[0032] In RPMI 1640 medium containing 10% fetal bovine serum (containing penicillin 100U / mL, streptomycin 100U / mL), placed at 37°C, saturated humidity, 5% CO 2 Routine subculture in an incubator.

[0033] 2. Subcuta...

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Abstract

The invention discloses an application of ovarian cancer cells in a medicine for treating pancreatic cancer, and belongs to the field of biological medicines. The ovarian cancer cells are obtained by culturing human ovarian cancer SKOV3 cells, the ovarian cancer cells and a pharmaceutically acceptable carrier are prepared into a medicine for treating and / or preventing pancreatic cancer, and administration treatment is carried out in a subcutaneous injection or surgical transplantation mode. Animal experiments prove that the ovarian cancer cells have great potential as drugs for treating pancreatic cancer, the good curative effect of the ovarian cancer cells on pancreatic cancer is disclosed for the first time, and an effective novel potential alternative therapy is provided for pancreatic cancer treatment.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a novel therapy for treating cancer with cancer cells, in particular to an application of ovarian cancer cells in anti-pancreatic cancer drugs. Background technique [0002] Pancreatic cancer is one of the common malignant tumors of the digestive tract. It is a very aggressive malignant tumor with rapid progression and poor prognosis. In recent years, the incidence of pancreatic cancer in my country is on the rise, and its morbidity and mortality are at the forefront of malignant tumors. At present, the only curative method for pancreatic cancer is surgical resection, but the five-year survival rate of patients undergoing surgery is less than 20%. Therefore, finding a better treatment form and treatment plan has become an urgent problem for pancreatic cancer. Although gemcitabine is used as a first-line drug in the chemotherapy of pancreatic cancer, due to the existence of primary and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/13A61P35/00
CPCA61K35/13A61K9/0019A61P35/00
Inventor 崔庆华
Owner 北京箭牧科技有限公司
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