Synthesis method of mesitylene-2-sulfonyl triazole

A technology for the synthesis of sulfone-triazole and its synthesis method, which is applied in the field of synthesis of mesityl-2-sulfone-triazole, achieving the effects of high purity and simple and easy-to-operate synthesis method

Pending Publication Date: 2022-02-08
宁夏常晟药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Mesityl-2-sulfone triazole is a derivative of triazole, and there is no report on its synthetic method in

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0016] Example 1

[0017] A method of synthesizing a trichlamine-2-sulfone-based triazole, including the following steps:

[0018] (1) 200 kg of carboxamide is added to the annulus, and stir it, 500 kg of amino thiourea, stir for 30min, turn on the reactor jacket steam temperature rise, temperature rise to 100 ° C, heat insulation reaction for 4 h, react, turn on the cycle water to cool down 25 ° C, 1,200 kg of methanol was added, and stirred was stirred, and 400 kg of potassium hydroxide was put into batch, the temperature was 40 ° C, stirred, and 2412 kg of compound A;

[0019] (2) 700 kg of hydrochloric acid is added to the reaction kettle, then 500 kg of water, open the frozen salted salt to start cooling, cool down to 3 ° C, then start addition of 500 kg of trichraphenneine, stir 0.5 h, slowly add 300 kg of sodium nitrite, drop After completion, the incubation is stirred for 2 h, resulting in a nitrogen to be used, checking the working nitrogen kettle and potassium salt kettl...

Example Embodiment

[0021] Example 2

[0022] A method of synthesizing a trichlamine-2-sulfone-based triazole, including the following steps:

[0023] (1) 200 kg of formamide is added to the annulus, and stir it, 300 kg of amino thiourea, stir for 30min, turn on the reactor jacket steam temperature rise, warm to 100 ° C, heat insulation reaction 4h, and turn on the cycle water after the reaction is passed 25 ° C, 1,200 kg of methanol was added, and stirred on stir, 400 kg of potassium hydroxide, controlled temperature at 40 ° C, stirred, ie 2503 kg of Compound A;

[0024] (2) 700 kg of hydrochloric acid is added to the reaction kettle, then 500 kg of water, open the frozen salted water to start cooling, cool down to 3 ° C, then start addition of raw plycemidine, stir 0.5 h, slowly add sodium nitrite, add 5 , The incubation is stirred for 2 h to obtain a nitrogen to be used, and the weight of the azurizol and the potassium salt is normal, set two pump flow speed, and start the two metering pumps at th...

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PUM

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Abstract

The invention belongs to the technical field of chemical intermediates, and particularly relates to a synthesis method of mesitylene-2-sulfonyl triazole. According to the method, formamide, thiosemicarbazide and the like are used as starting raw materials, mesitylene-2-sulfonyl triazole is synthesized through three steps, the synthesis method is simple and easy to operate, and the synthesized product is high in purity.

Description

technical field [0001] The invention belongs to the technical field of chemical intermediates, and in particular relates to a synthesis method of mesityl-2-sulfone triazole. Background technique [0002] Triazole is an organic compound with a chemical formula of CHN. It is widely used in the synthesis of pesticides such as triazole, paclobutrazol, uniconazole, and diniconazole. It is a white needle-like crystal. Industrial products are light yellow or brown needle-like crystals. powerful. Uses It is an intermediate of pesticides and medicines, widely used in the synthesis of pesticides such as triclobutrazol, paclobutrazol, uniconazole, and diniconazole. [0003] Mesityl-2-sulfone triazole is a derivative of triazole, and there is no report on its synthetic method in the prior art, and there is an urgent need for an efficient synthesis of mesityl-2-sulfone method based on triazoles. Contents of the invention [0004] Aiming at the problems of the prior art described abo...

Claims

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Application Information

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IPC IPC(8): C07D249/12
CPCC07D249/12
Inventor 陈健龙金璐仪
Owner 宁夏常晟药业有限公司
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