Gabapentin soft chewable tablet preparation, and preparation method and application thereof

A technology of gabapentin and soft chewing, which is applied in pill delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc. It can solve problems such as unsatisfactory stability, improve subjective initiative, reduce the formation of impurities, and administer food and drug convenient effect
CN114028352APending Publication Date: 2022-02-11上海汉维生物医药科技有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
上海汉维生物医药科技有限公司
Publication Date
2022-02-11

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Abstract

The invention provides a gabapentin soft chewable tablet preparation, and a preparation method and application thereof. The gabapentin soft chewable tablet preparation comprises gabapentin, a phagostimulant, a filler and a wetting agent, the wetting agent is a mixture of glycerol and polyethylene glycol, the content of polyethylene glycol is 20-40 wt%, the phagostimulant is selected from chicken liver powder, beef powder or chicken powder and the like, and the filler comprises common auxiliary materials such as microcrystalline cellulose, corn starch, potato starch or pregelatinized starch. The preparation method comprises the following steps: mixing gabapentin, the phagostimulant and the filler in a wet type granulator, then dropwise adding the wetting agent into the wet type granulator, and carrying out granulation, granule finishing and tabletting. According to the invention, feeding and administration are convenient, and the subjective initiative of pet eating can be improved by adding the phagostimulant; and soft tablets chewable in the mouth can be prepared through the high viscosity property of a moisturizer such as glycerin, and meanwhile the moisturizer such as glycerin can just play a role of a stabilizer for gabapentin.
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Description

technical field

[0001] The invention belongs to the technical field of pharmacy, and in particular relates to a gabapentin soft chewable tablet preparation and a preparation method and application thereof. Background technique

[0002] Gabapentin, also known as Neurontin, has been shown to prevent epilepsy in various animal models. It is the first anti-epileptic drug developed by Warner-Lambert in the United States, and it was first listed in the UK in 1993.

[0003] In recent years, in addition to the treatment of epilepsy, gabapentin can also be used as an adjuvant drug for postoperative analgesia and reduce the use of antiemetics;

[0004] In addition, gabapentin has the characteristics of high therapeutic index and safety, mainly characterized by good tolerance, low toxicity, no teratogenicity, mutagenicity, and short-term and mild side effects.

[0005] Therefore, this product is mainly used for pain relief (neuropathic pain, chronic pain) and emotional comfort and anx...

Claims

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