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Medicine for improving pregnancy rate and/or embryo survival rate during embryo transplantation and application of medicine

A technology of embryo transfer and pregnancy rate, which is applied in the field of embryo transfer, can solve the problems of restricting the application of embryo transfer technology and high production costs, and achieve the effects of improving embryo survival rate, pregnancy rate and embryo survival rate

Pending Publication Date: 2022-02-18
草原和牛投资有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the high genetic quality and production cost of transplanted embryos, the death of early embryos brings huge economic losses, which directly limits the application of embryo transfer technology in production

Method used

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  • Medicine for improving pregnancy rate and/or embryo survival rate during embryo transplantation and application of medicine
  • Medicine for improving pregnancy rate and/or embryo survival rate during embryo transplantation and application of medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A drug for improving the pregnancy rate and / or embryo survival rate of embryo transfer, consisting of 1 g of tofenac and 2.5 g of flunixin meglumine.

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Abstract

The invention relates to the technical field of embryo transplantation, in particular to a medicine for improving a pregnancy rate and / or an embryo survival rate during embryo transplantation and application of the medicine. The effective component of the medicine comprises an epoxidase inhibitor. According to the medicine provided by the invention, an epoxidase inhibitor (tolfenamic acid and / or flunixin meglumine) is utilized to inhibit the activity of epoxidase (COX) and influence the synthesis of prostaglandin (PGF2alpha), so the function of corpus luteum is favorably maintained, and the pregnancy rate of transplanted embryos and the survival rate of the embryos are further improved. According to embodiments in the invention, compared with a control group, the medicine has the advantages that the pregnancy rate of of transplanted embryos is increased by 14.6%-33.0%, and the survival rate of the embryo is increased by 42.3%-86.2%.

Description

technical field [0001] The invention relates to the technical field of embryo transfer, in particular to a medicine and application for improving the embryo transfer pregnancy rate and / or embryo survival rate. Background technique [0002] Assisted reproductive techniques, including embryo transfer, are often used for genetic improvement of livestock and, in some cases, to overcome infertility in top elite individuals. However, the efficiency of livestock embryo transfer technology still has not reached the ideal level. For example, the conception rate of fresh embryos in dairy cows is only 55% to 60%, the conception rate of thawed embryos after freezing is only 45% to 50%, and the conception rate of in vitro fertilized embryos is 30%. %, while the conception rate of somatic cell nuclear transfer cloned embryos is only 10% to 20%. The efficiency of embryo transfer in sheep and goats is basically the same. Through the comparison of the above figures, it is found that nearly...

Claims

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Application Information

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IPC IPC(8): A61K31/44A61K31/196A61P15/06
CPCA61K31/196A61K31/44A61P15/06A61K2300/00
Inventor 何牧仁
Owner 草原和牛投资有限公司
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