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Red platelet-rich fibrous protein biological injection material and application thereof

A platelet-rich and fibrin-rich technology, applied in the direction of medical raw materials derived from mammals, drug combinations, skin diseases, etc., can solve the problem of unclear influence on dermal papilla cells, and achieve the effect of no risk of immune rejection and easy access to preparation

Pending Publication Date: 2022-03-11
NORTHERN JIANGSU PEOPLES HOSPITAL
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The effect of injectable platelet-rich fibrin (i-PRF) on dermal papilla cells, the key cell seed for hair follicle regeneration, is currently unknown

Method used

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  • Red platelet-rich fibrous protein biological injection material and application thereof
  • Red platelet-rich fibrous protein biological injection material and application thereof
  • Red platelet-rich fibrous protein biological injection material and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1 Preparation of injectable platelet-rich fibrin

[0029] This embodiment involves 6 volunteers, 3 males and 3 females, age range 22-26 years old, no abnormal blood test reports and smokers.

[0030] The preparation steps of platelet-rich fibrin injection are as follows: After obtaining human peripheral venous blood, immediately transfer it to a centrifuge tube, and centrifuge at 60g for 3 minutes (the centrifugal force of 60g is equivalent to 700rpm on a centrifuge with a diameter of 110mm). After centrifugation, whole blood can be separated into three layers, such as figure 1 As shown in (1), from top to bottom includes: yellow upper layer ( figure 1 Middle A layer), middle buffy coat ( figure 1 Middle B layer) to the red lower layer containing red blood cells ( figure 1 middle layer C). Use the tip of the pipette tip on the middle buffy coat, yellow platelet-rich fibrin (yellow i-PRF, Yellow i-PRF) can be obtained in the yellow upper layer; under the y...

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Abstract

The invention discloses a red platelet-rich fibrin biological injection material, which is obtained by the following method: taking peripheral whole blood, centrifuging 60g of the peripheral whole blood for 3 minutes, dividing the blood into three layers, and taking the middle layer to obtain the injection material red i-PRF; the material is rich in cell number and growth factor concentration (VEGF, TGF-beta1, EGF and IGF-1), can improve the activity, proliferation, migration, alkaline phosphatase activity and hair induction capacity of human hair papilla cells (HDPC), can be used as a hair follicle regeneration material to be applied to alopecia treatment, and particularly, the material is derived from an autologous body, can reduce autoimmune response, and has a relatively high application prospect.

Description

technical field [0001] The application relates to the field of biotechnology, in particular to a red injectable platelet-rich fibrin biomaterial and its application in hair follicle regeneration. Background technique [0002] The peripheral veins of the human body will be the plasma layer, the white blood cell and platelet layer, and the red blood cell layer from top to bottom after standing still naturally. General plasma layer, white blood cells and platelet layer is called serum. Serum is rich in growth factors, platelets, white blood cells, etc. [0003] In the 1870s, it was found that by properly adjusting the centrifugation mode and secondary centrifugation, the ratio of growth factors, white blood cells and platelets in the serum can be increased, that is, a serum with high concentration of growth factors, rich in platelets and white blood cells can be obtained, and the It is named platelet rich plasma (PRP), which is also the first generation of platelet concentrat...

Claims

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Application Information

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IPC IPC(8): A61K35/16A61K35/19A61P17/14
CPCA61K35/16A61K35/19A61P17/14
Inventor 侯团结卢孔烨李平松韩启雯马泽坤颜青青
Owner NORTHERN JIANGSU PEOPLES HOSPITAL
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