Manufacturing method and using method of recording electrode array capable of being implanted into multiple brain areas for long time

Abstract

The invention discloses a method for manufacturing a multi-brain-region recording electrode array capable of being implanted for a long time. The method comprises the steps that firstly, the positions and the depths of multiple target brain regions need to be determined according to experimental requirements before the electrode array is manufactured; 2, each electrode hole is connected with an electrode adapter jack, an electrode adapter adopts a standard Omnetics joint, and at most 32 electrode wires can be connected; thirdly, electrode wires are nickel-chromium alloy or tungsten metal wires and are directly welded to the tinned holes; 4, protecting each electrode wire by using a carbon fiber tube as an electrode sleeve, and exposing the tip of the electrode wire by 0.5-1mm; and 5, inserting the electrode adapter pin header into a corresponding jack on the electrode base, and welding. Compared with the prior art, the electrode array has the advantages that protection on the electrode wire is increased, the risk that the electrode abuts against the skull to be bent during implantation is reduced, the success rate of implantation is increased by adopting a split implantation mode, meanwhile, the electrode array can cover the whole brain range of an animal, and detection and collection of whole brain nerve electrophysiological signals are achieved.

Description

technical field [0001] The invention relates to the technical field of electrode arrays, in particular to a method for manufacturing and using a recording electrode array that can be implanted in multiple brain regions for a long time. Background technique [0002] The detection and acquisition of electrical signals of the brain is not only an indispensable method for brain science research, but also an important tool for the diagnosis of brain diseases. The use of electrophysiological techniques to record electrical signals in multiple brain regions can help understand the function of related circuits between different brain regions and brain nuclei and detect abnormal lesions. At present, the detection and acquisition of neuroelectric signals in multiple brain regions is usually performed by implanting multiple electrodes or multiple groups of electrodes in parallel. When multiple electrodes are implanted in stages, the head space is limited, and it is difficult to fix mul...

AI Technical Summary

Problems solved by technology

If a rigid electrode wire or electroacupuncture is used, it is easy to bend or break when it touches the skull during implantation. If a flexible electrode wire or electroacupuncture is used, it is also easy to touch the skull or dura mater and become bent, resulting in a decline in electrode recording performance

[0003] At present, most of the detection and acquisition of neurophysiological signals in multiple brain regions is the parallel implantation of multiple electrodes or groups of electrodes, which brings many problems: when multiple electrodes are implanted in batches, the head space is limited, It is difficult to fix multiple electrodes at the same time, which will increase the burden on the head of the experimental animal; if multiple sets of electrodes are parallel, it is impossible to record multiple brain regions that are far apart at the same time; when the array electrodes are implanted, it is easy to touch the skull and bend, which will affect the performance of the electrodes; Electrode implantation in multiple brain regions generally takes too long, and the risk of animal death is greater

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