Euphausia superba oil gel capsule and preparation method thereof

An Antarctic krill and oil gel technology, which is applied in capsule delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve problems such as deterioration, krill oil leakage, and difficult sealing of tablets

Pending Publication Date: 2022-03-25
QINGDAO BINHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the inventors have found that the chemical properties of the above-mentioned active substances in krill oil are unstable, and they are easily oxidized and decomposed in the air to deteriorate, and the sealing of the tablet is difficult to effectively protect the krill oil contained therein. Easy to cause tablet drug load l...

Method used

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  • Euphausia superba oil gel capsule and preparation method thereof
  • Euphausia superba oil gel capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A preparation method of Antarctic krill oil gel capsule, comprising steps:

[0022] (1) Weigh gelatin, glycerin, water, and hydrophilic silica nanopowder according to the ratio of 1.0 parts by weight: 0.5 parts by weight: 1.0 parts by weight: 0.2 parts by weight; of silica nanopowder.

[0023] (2) Put the glycerin, water and hydrophilic silica nano-powder in step (1) in a plastic bucket, heat to 65°C and keep stirring for 35 minutes to disperse the silica nano-powder evenly, then add the gelatin, continue Stir to melt the gelatin completely to obtain gelatin glue, set aside.

[0024] (3) Use the gelatin solution prepared in step (2) as the capsule material, use Antarctic krill oil as the capsule content, and use the soft capsule machine (model HRS-250) to wrap the capsule content in the capsule material Soft capsules were formed in the process, the pilling temperature was 22°C, and the relative humidity was 50%. After completion, the obtained capsules were first dried...

Embodiment 2

[0026] A preparation method of Antarctic krill oil gel capsule, comprising steps:

[0027] (1) Weigh gelatin, composite softener, water, methyl p-hydroxybenzoate nanopowder according to the ratio of 1.0 parts by weight: 0.6 parts by weight: 1.07 parts by weight: 0.22 parts by weight; the composite softener is glycerin and D sorbic acid The mixture that alcohol forms, wherein, described D sorbitol is 8% of glycerin quality.

[0028] (2) Put the glycerin, water and methyl p-hydroxybenzoate nano-powder in step (1) in a rubber bucket, heat to 60°C and keep stirring for 40 minutes to disperse the methyl p-hydroxybenzoate nano-powder evenly, then add the Describe the gelatin, and continue to stir to melt the gelatin completely to obtain a gelatin glue solution, which is set aside.

[0029] (3) Use the gelatin solution prepared in step (2) as the capsule material, use Antarctic krill oil as the capsule content, and use the soft capsule machine (model HRS-250) to wrap the capsule con...

Embodiment 3

[0031] A preparation method of Antarctic krill oil gel capsule, comprising steps:

[0032] (1) Weigh gelatin, compound softener, water, and ethyl p-hydroxybenzoate nanopowder according to the ratio of 1.0 parts by weight: 0.4 parts by weight: 0.82 parts by weight: 0.13 parts by weight; the compound softener is glycerin and mannose The mixture that alcohol forms, wherein, described mannitol is 13% of glycerol quality.

[0033] (2) Put the glycerin, water and ethyl p-hydroxybenzoate nano-powder in step (1) in a rubber bucket, heat to 65°C and keep stirring for 40 minutes to disperse the ethyl p-hydroxybenzoate nano-powder evenly, then add the Describe the gelatin, and continue to stir to melt the gelatin completely to obtain a gelatin glue solution, which is set aside.

[0034] (3) Use the gelatin solution prepared in step (2) as the capsule material, use Antarctic krill oil as the capsule content, and use the soft capsule machine (model HRS-250) to wrap the capsule content in ...

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Abstract

The invention relates to an euphausia superba oil gel capsule and a preparation method thereof, the method comprises the following steps: (1) mixing gelatin, a softener, water and a modifier, heating and uniformly stirring to obtain a gelatin solution, the modifier being a food additive with hydroxyl; and (2) taking gelatin liquid as a capsule wall material, taking euphausia superba oil as a capsule content, and wrapping the capsule content in the capsule wall material to form a soft capsule, thereby obtaining the euphausia superba oil soft capsule. By modifying the capsule wall material, when eicosapentaenoic acid and docosahexaenoic acid in the krill oil are in contact with the inner wall of the soft capsule, hydrophilic carboxyl groups on the eicosapentaenoic acid and docosahexaenoic acid can be combined with hydroxyl groups on the inner wall surface of the soft capsule to form ester groups, and the ester groups are hydrophobic groups; and equivalently, a barrier film layer is formed on the inner wall surface of the soft capsule, so that other krill oil in the capsule can be prevented from continuously contacting with the inner wall surface of the soft capsule, and the problems of hardening and embrittlement of the soft capsule caused by water absorption of the krill oil are well avoided.

Description

technical field [0001] The invention relates to the technical field of shrimp oil, in particular to an Antarctic krill oil gel capsule and a preparation method thereof. Background technique [0002] Antarctic krill is a kind of krill that lives in the waters of Antarctica in the Antarctic Ocean. Krill is the marine organism with the highest protein content that has been found so far, with a protein content of more than 50%. Krill oil is obtained by catching krill and pressing it into krill meal, then extracting krill oil from krill meal with alcohol, removing alcohol after extraction, and then purifying through multiple processes. Extract, which contains active substances such as OMEGA-3 unsaturated fatty acids, eicosapentaenoic acid, docosahexaenoic acid and astaxanthin. Studies have shown that these active substances have good effects on the treatment of cardiovascular, nervous, bone and joint, vision, skin, etc. [0003] In order to facilitate taking, krill oil is gener...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K35/612A61K47/42A61K47/04A61K47/12A61K47/10A61K47/26A61K47/02A61K47/36A61K47/32A61P9/00A61P25/00A61P19/08A61P19/02A61P27/02A61P17/00
CPCA61K9/4825A61K9/4816A61K35/612A61P9/00A61P25/00A61P19/08A61P19/02A61P27/02A61P17/00
Inventor 江晓张竞竞刘婷岳启安周猛鲍淑兰
Owner QINGDAO BINHAI UNIV
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