Detection method of methyl bromoacetate

A kind of technology of methyl bromoacetate and detection method, applied in the detection field of methyl bromoacetate, can solve problems such as inability to learn from detection, and achieve the effect of being difficult to separate

Active Publication Date: 2022-04-01
BEIJING JINCHENG TAIER PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This patent is aimed at the determination of the content of cyclopropyl methyl ketone, a pharmaceutical intermediate, which is highly specific and cannot be used for reference in the detection of other drugs.

Method used

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  • Detection method of methyl bromoacetate
  • Detection method of methyl bromoacetate
  • Detection method of methyl bromoacetate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] (1) The preparation method of the reference substance solution is to measure 1ml of methanol stock solution, 1ml of methyl methoxyacetate stock solution, 1ml of methoxyacetic acid stock solution, 1ml of bromoacetic acid stock solution and 1ml of methyl bromoacetate stock solution, and use Dilute with acetonitrile to 10ml, shake well, and obtain.

[0048] The preparation method of methanol stock solution is to take 50mg of methanol, dilute to 10ml with acetonitrile, shake well, and obtain;

[0049] The preparation method of methyl methoxyacetate stock solution is to take 50 mg of methyl methoxyacetate, dilute to 10 ml with acetonitrile, shake well, and obtain;

[0050] The preparation method of methoxyacetic acid stock solution is to take 50mg of methoxyacetic acid, dilute to 10ml with acetonitrile, shake well, and obtain;

[0051] The preparation method of bromoacetic acid stock solution is to take 50 mg of bromoacetic acid, dilute to 10 ml with acetonitrile, shake wel...

Embodiment 2

[0096] (1) The preparation method of the reference substance solution is to measure 1ml of methanol stock solution, 1ml of methyl methoxyacetate stock solution, 1ml of methoxyacetic acid stock solution, 1ml of bromoacetic acid stock solution and 1ml of methyl bromoacetate stock solution, and use Dilute with acetonitrile to 10ml, shake well, and obtain.

[0097] The preparation method of methanol stock solution is to take 50mg of methanol, dilute to 10ml with acetonitrile, shake well, and obtain;

[0098] The preparation method of methyl methoxyacetate stock solution is to take 50 mg of methyl methoxyacetate, dilute to 10 ml with acetonitrile, shake well, and obtain;

[0099] The preparation method of methoxyacetic acid stock solution is to take 50mg of methoxyacetic acid, dilute to 10ml with acetonitrile, shake well, and obtain;

[0100] The preparation method of bromoacetic acid stock solution is to take 50 mg of bromoacetic acid, dilute to 10 ml with acetonitrile, shake wel...

Embodiment 3

[0113] (1) The preparation method of the reference substance solution is to measure 1ml of methanol stock solution, 1ml of methyl methoxyacetate stock solution, 1ml of methoxyacetic acid stock solution, 1ml of bromoacetic acid stock solution and 1ml of methyl bromoacetate stock solution, and use Dilute with acetonitrile to 10ml, shake well, and obtain.

[0114] The preparation method of methanol stock solution is to take 50mg of methanol, dilute to 10ml with acetonitrile, shake well, and obtain;

[0115] The preparation method of methyl methoxyacetate stock solution is to take 50 mg of methyl methoxyacetate, dilute to 10 ml with acetonitrile, shake well, and obtain;

[0116] The preparation method of methoxyacetic acid stock solution is to take 50mg of methoxyacetic acid, dilute to 10ml with acetonitrile, shake well, and obtain;

[0117] The preparation method of bromoacetic acid stock solution is to take 50 mg of bromoacetic acid, dilute to 10 ml with acetonitrile, shake wel...

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Abstract

The invention belongs to the technical field of medicine detection, and particularly relates to a detection method of methyl bromoacetate. The content of methanol, methoxyacetic acid, bromoacetic acid and methyl methoxyacetate in methyl bromoacetate is measured by adopting a gas chromatographic method. According to the method, methanol, methyl methoxyacetate, methoxyacetic acid, methyl bromoacetate and bromoacetic acid can be effectively separated, and the contents of methanol, methoxyacetic acid, bromoacetic acid and methyl methoxyacetate in methyl bromoacetate can be rapidly, efficiently and accurately determined.

Description

technical field [0001] The invention belongs to the technical field of drug detection, and in particular relates to a detection method of methyl bromoacetate. Background technique [0002] Methyl bromoacetate is a chemical raw material that can be used in the synthesis of herbicides and as an intermediate in the synthesis of dyes and drugs. When using gas chromatography to measure the content of methyl bromoacetate in the prior art, the temperature of the chromatographic column is usually a constant temperature, and the area normalization method is used to calculate its content with the peak area, but it cannot effectively separate the methyl bromoacetate that may contain other impurities. [0003] Chinese patent CN 113049712 A discloses a method for determining the content of cyclopropyl methyl ketone, comprising the steps of: (i) providing a sample solution to be tested and an internal standard standard solution; (ii) making the sample solution to be tested and the intern...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/04G01N30/86
CPCY02P20/55
Inventor 孟庆博李莉安勇邵旭黄海玉王立茹向宏艳段月晓崔娅丽
Owner BEIJING JINCHENG TAIER PHARMA CO LTD
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