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Multi-layer micro-fluidic organ chip with multi-stage alveolar tube structure and manufacturing method of multi-layer micro-fluidic organ chip

An organ-on-a-chip and tube structure technology, applied in chemical instruments and methods, laboratory containers, biochemical equipment and methods, etc., can solve the problem of not being able to truly reveal the systemic, poor compliance, and overall research of fluid and particle transport Inaccurate and other problems, to achieve the effect of improving research accuracy, convenient operation, and simple principle

Pending Publication Date: 2022-04-12
ZHEJIANG UNIV
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  • Abstract
  • Description
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Problems solved by technology

However, the above-mentioned single-stage alveolar duct model cannot truly reveal the systematic nature of fluid and particle transport, while the structure designed by the multi-level alveolar duct model does not match the real human body in terms of size, and the overall research is not accurate

Method used

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  • Multi-layer micro-fluidic organ chip with multi-stage alveolar tube structure and manufacturing method of multi-layer micro-fluidic organ chip
  • Multi-layer micro-fluidic organ chip with multi-stage alveolar tube structure and manufacturing method of multi-layer micro-fluidic organ chip

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Embodiment Construction

[0027] The present invention will be described in further detail below in conjunction with the accompanying drawings and specific embodiments.

[0028] like figure 1 As shown, the present invention provides a multilayer microfluidic organ chip with a multi-level alveolar duct structure, including: microfluidic channel chip layer 1 , intermediate thin film chip layer 2 and pressure chamber chip layer 3 .

[0029] The microfluidic pipeline chip layer 1 includes a main fluid channel 11, a simulated multi-level alveolar duct structure microchannel 12, a transitional microchannel and an alveolar sac structure 13, and a microfluidic pipeline fluid access channel 14, a main fluid channel 11, and a simulated multi-level alveolar duct The structural microchannel 12 is connected with the transitional microchannel and the alveolar sac structure 13; the main fluid channel 11 is used for the flow of working fluid, and the main fluid channel 11 includes the inlet and outlet of the main flui...

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Abstract

The invention discloses a multi-layer micro-fluidic organ chip with a multi-stage alveolar tube structure and a manufacturing method of the multi-layer micro-fluidic organ chip. The lung organ chip mainly comprises three parts, namely a micro-flow pipeline chip layer, a middle film chip layer and a pressure chamber chip layer, wherein the micro-flow pipeline chip layer and the pressure chamber chip layer are positioned on the upper side and the lower side of the middle film chip layer. The device is used for researching fluid flow characteristics and aerosol deposition laws in a respiratory alveolar region in the respiratory tract of a human body, the device is simple in operation principle, the flow rate of fluid entering an inlet of the upper microflow pipeline can be accurately controlled, and the research accuracy is improved.

Description

technical field [0001] The invention belongs to the field of microfluidic organ chips, and in particular relates to a multilayer microfluidic organ chip with a multi-level alveolar duct structure and a manufacturing method thereof. Background technique [0002] Human survival is closely related to the atmosphere. In recent years, with the development of the economy, the quality of the atmospheric environment has gradually deteriorated. The smog caused by air pollution not only has great harm to the human body, but also endangers environmental protection and sustainable urban development. The study found that PM in the atmosphere 2.5 It is possible to greatly increase the probability of a person suffering from various respiratory diseases. Studying the complex flow deep in the human lung and the transportation rules of micro-nano particles can help us better understand the process of harmful aerosols in the environment invading the human body and the transport mechanism of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M3/00C12M1/00B01L3/00
Inventor 胡国庆裘岩
Owner ZHEJIANG UNIV
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