Detection platform for measuring cell S parameter and detection method thereof
A detection platform and cell technology, applied in biochemical equipment and methods, specific-purpose bioreactors/fermenters, biochemical instruments, etc., can solve the problems of professional knowledge in the long processing process, and reduce the difficulty of control and test personnel needs, reduce testing costs, and control error effects
Pending Publication Date: 2022-04-15
HANGZHOU DIANZI UNIV
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Problems solved by technology
However, the biochemical detection method requires professional reagents and equipment, a clean detection environment, a long process and expertise in biochemical processing.
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[0031] The technical solutions of the present invention will be further described below with reference to the accompanying drawings.
[0032] Such as figure 1 As shown, a detection platform for measuring the cell S parameter, including the microfluidic module, the probe station module, the imaging module, and the computer unit 35. The microfluidic module includes a syringe 16, a microfluidic pump 17, an input conduit 18, a cell capture detecting sensor, an output conduit 21, and a solution collector 22. The syringe 16 uses a 1 ml medical syringe. Cell capture detecting sensors are used to achieve cell capture, release, and S parameter detection, which are provided with micro track for cell capture, and a waveguide electrode for S-parameter detection. A input port 1, an output port 2, a control port 3, a capture channel 6, and a blocking structure are provided on the micro track. The micro-track can limit the cells to the detection region 8.
[0033] The syringe 16 contains a solut...
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Abstract
The invention discloses a detection platform for an S parameter of a cell. The platform can be used for observing and recording the position and the S parameter of the cell. The platform comprises four functional blocks, namely a micro-fluidic module, a microscopic imaging module, a probe station and a data processing unit. Wherein the micro-fluidic module is used for conveying a cell sample to a detection area; the microscopic imaging module is used for amplifying a detection area; the probe station module is used for realizing connection of a sensor and acquiring an S parameter; and the data processing unit realizes cell observation and system control. In the test platform of the S parameter of the whole cell, the microfluidic technology and the electrical measurement are connected through a cell capture detection sensor, and the sensor comprises a microflow pipeline and an electrode which are specially designed. The whole test platform can effectively observe the capture of the cells and measure the S parameter of the cells.
Description
Technical field [0001] The present invention relates to the field of microfluidic control and electrical measurement, and more particularly to the micro delivery of a cell solution, the cell observation of the area and the S-parameters of the cells. The proposed test platform enables the delivery of cells, observing the measurement of the S parameters. Background technique [0002] Many drug research and development requires detection of specific cells, such as effectively realizing specific cells, has always been concerned about researchers. The method for detecting the biochemical properties of cells has been widely popular and mature, such as antigen antibody reactions, polymerase chain reaction (PCR), fluorescent markers, and the like. However, biochemical testing requires professional reagents and equipment, clean detection environments, long processing processes and biochemical treatment expertise. How to efficiently and quickly complete cell tests is important. In recent y...
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IPC IPC(8): C12M1/34C12M1/36C12M1/00
Inventor 黄汐威陈津苏江涛孙玲玲
Owner HANGZHOU DIANZI UNIV