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Application of sodium taurocholate as synergist for antituberculosis antibiotic

A technology of sodium taurocholate and antibiotics, applied in the field of sodium taurocholate, can solve the problems of reducing the effect of antibiotics, and achieve the effects of reducing dosage, improving drug efficacy, and reducing strength

Inactive Publication Date: 2004-03-31
黄林君
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When antibiotics act on Mycobacterium tuberculosis, due to its strong and thick cell membrane barrier, the effect of antibiotics is reduced, especially due to the strong adaptive ability of Mycobacterium tuberculosis, when this antibiotic is used for the second time, it will develop drug resistance

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] Embodiment 1: Using sodium taurocholate as an anti-tuberculosis antibiotic synergist, the antibiotic uses rifampicin, adopts an in vitro drug-resistant Mycobacterium tuberculosis culture method, the dosage of rifampicin is 50 or 250 μg / ml, sodium taurocholate and Rifampicin is administered at a ratio of 1:0.5 (mass ratio). Controlled experiments prove that sodium taurocholate has a significant synergistic effect on rifampicin, and has a strong killing effect on drug-resistant tuberculosis strains.

Embodiment 2

[0010] Embodiment two: take sodium taurocholate as anti-tuberculosis antibiotic synergist, antibiotic selects streptomycin for use, adopts in vitro drug-resistant tuberculosis culture mode, streptomycin dosage is 50 or 250 μ g / ml, sodium taurocholate and Streptomycin is used in a ratio of 1:1 (mass ratio). Control experiments have shown that sodium taurocholate has a significant synergistic effect on streptomycin and has a strong killing effect on drug-resistant tuberculosis strains.

Embodiment 3

[0011] Embodiment 3: Using sodium taurocholate as an anti-tuberculosis antibiotic synergist, the antibiotic is selected from isoniazid, adopts in vitro drug-resistant Mycobacterium tuberculosis culture method, the dosage of isoniazid is 50 or 250 μ g / ml, sodium taurocholate and Isoniazid is administered at a ratio of 1:2.5 (mass ratio). Controlled experiments prove that sodium taurocholate has a significant synergistic effect on isoniazid and has a strong killing effect on drug-resistant tuberculosis strains.

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PUM

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Abstract

The present invention relates to a synergist for antituberculotic antibiotic medicines, such as streptomycin, isoniazid, rifampin, kanamycin, capreomycin, ethambutol, PASA, thiacetazone or prothionamide, etc. It is characterized by that the described synergist is sodium taurocholate, possesses the action of solving cell membrane of mycobacterium tuberculosis, can reduce strength of cell membrane of mycobacteruim tuberculosis, and can make antibiotic medicine easily come into the cell of mycobacteruim tuberculosis to kill mycobacteruim tuberculosis, so that it can raise medicinal effect of antibiotic medicine, and can reduce its does to further reduce its toxic side effect.

Description

technical field [0001] The invention relates to the use of sodium taurocholate, in particular to sodium taurocholate used as an anti-tuberculosis antibiotic synergist. Background technique [0002] Tuberculosis is the oldest disease in human history, and it has claimed countless lives with impunity. According to information, since Koch discovered tuberculosis in 1882, the number of deaths due to tuberculosis has reached 200 million. Since 1985, the global tuberculosis epidemic has shown a sharp upward trend, and the death toll of tuberculosis patients in the world has increased from 2.5 million in 1990 to 3.5 million in 2000. 75% of tuberculosis deaths occur in the most productive age group (15-45 years old), 2 billion people have been infected with tuberculosis in the world, and the annual infection rate is 1%, that is, about 65 million people are infected with tuberculosis every year. Tuberculosis has once again become a social public health problem and a disease that en...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/56A61K31/575A61P31/06
Inventor 胡永祥
Owner 黄林君
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