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Injectable hydrogels for vascular embolism

A hydrogel, medical technology, applied in the field of injectable hydrogel

Pending Publication Date: 2022-04-19
SHANGHAI RUINING BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the gel forms quickly in an in vitro environment and has long-term stability in aqueous solution, the hydrogel can only meet the requirements for radiation protection as a medical radiotherapy protective gasket. Can it form a stable gel in blood vessels? and maintain a stable embolism effect is unknown

Method used

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  • Injectable hydrogels for vascular embolism
  • Injectable hydrogels for vascular embolism
  • Injectable hydrogels for vascular embolism

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1 The effect of the ratio of aldehyde groups to amino groups in the hydrogel on the intravascular gel-forming ability In order to test the intravascular gel-forming ability of different hydrogel formulations, this example uses a double syringe to inject two-component water The gel was injected into rat arteries, and the two-component hydrogel was formed by mixing liquid A and liquid B through a double syringe. First, 200 mg of ester bond-linked phenylaldehyde-terminated 8-arm polyethylene glycol (molecular weight: 15 kDa) was dissolved in 1 mL of phosphate buffer (pH 5.6) as liquid A. According to different molar ratios shown in Table 1, borax buffer (pH9.2) solutions with different contents of polylysine and polyethyleneimine (M.W.1.8K) were configured as B solution. A and B solutions were mixed and injected to obtain hydrogels, and hydrogel precursors of different formulations were injected into rat renal arteries to test the ability to form gels in blood vess...

Embodiment 2

[0037] Example 2 The ratio of aldehyde groups to amino groups in the hydrogel and the influence of PEG concentration on the vascular swelling rate of the gel The swelling rate of the gel in blood is very important for effective vascular embolism, and the swelling rate is too low (negative swelling) The hydrogel shrinks after gelling, which prevents the hydrogel from filling the blood vessel and effectively embolizing it. This example examines the swelling rate of the hydrogel in simulated blood, and the swelling rate of the gel meeting the embolism condition should be greater than 0.

[0038] According to the different final concentrations of polyethylene glycol shown in Table 2, different masses of ester-linked benzaldehyde-terminated 8-arm polyethylene glycol (molecular weight 15 kDa) were dissolved in 1 mL of phosphate buffer (pH 5.6 ), as liquid A. According to the different molar ratios shown in Table 2, the borax buffer (pH9.2) solutions with different contents of polyl...

Embodiment 3

[0043] The stability of the gel in the blood is very important for effective vascular embolization, which needs to last for a period of time to achieve good results. When the gel stability time is too short, the time to form an effective embolism is too short, resulting in poor effect. The inventor's early research found that the molar ratio of the amino group of polylysine to the aldehyde group of polyethylene glycol affects the stability of the hydrogel (the amino group of polylysine and the 8-PEG-amide-BA aldehyde in the aqueous solution environment in vitro When the molar ratio of the base is greater than or equal to 0.4, the stability of the hydrogel exceeds one month), this example investigates the stability of the hydrogel in simulated blood. First, 200 mg of ester-linked benzaldehyde-terminated 8-arm polyethylene glycol (molecular weight: 15 kDa) was dissolved in 1 mL of phosphate buffer (pH 5.6) as liquid A. According to different molar ratios shown in Table 3, borax...

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Abstract

The invention discloses injectable hydrogel for vascular embolism, which is formed by in-situ crosslinking of aldehyde-terminated star-shaped multi-arm polyethylene glycol, polyethyleneimine and polylysine, the molar ratio of aldehyde to amino in polyethyleneimine is 1: (0.6-5), and the molar ratio of aldehyde to amino in polylysine is 1: (0-5). The in-vitro gelling time of the hydrogel is equal to or less than 8 seconds, namely 8 seconds, and the hydrogel can quickly embolize blood vessels to cause necrosis of target organs or tissues.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to an injectable hydrogel for blood vessel embolism, which can be used as a blood vessel embolism agent to block diseased or injured blood vessels. Background technique [0002] Vascular embolization refers to the intentional blockage of diseased or injured blood vessels with embolizing agents, which can be used to treat many vascular diseases, including hemorrhages, aneurysms, vascular malformations, and tumors with a rich blood supply. Different types of embolic agents are currently used clinically, including coils, microspheres, and liquid emboli, among others. [0003] High molecular polymers are mostly used in the preparation of liquid vascular embolism agents. Literature reports a kind of liquid embolic product, and high molecular polymer is dissolved in the organic solvent DMSO, after the high molecular solution is injected into blood vessel, solid embolism i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L71/02C08L79/02C08L77/04C08J3/075C08J3/24A61L24/04A61L24/06A61L24/00
CPCC08J3/075C08J3/246A61L24/043A61L24/0031A61L24/001A61L2400/06A61L2430/36C08J2371/02C08J2479/02C08J2477/04C08J2379/02C08J2471/02C08J2377/04C08L79/02C08L71/02C08L77/04
Inventor 张红贵陈亮潘震
Owner SHANGHAI RUINING BIOTECH CO LTD
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