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Application of urolithin A in preparation of medicine for preventing or treating senile osteoporosis

A technology for osteoporosis and urolithin, which is applied in the field of medicine to achieve the effect of protecting bone mass and reducing toxicity

Pending Publication Date: 2022-04-29
THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] At present, there is no literature report about the influence of urolithin A on osteoblasts, and whether urolithin A has a therapeutic effect on senile osteoporosis. Based on this, the present invention also comes from

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  • Application of urolithin A in preparation of medicine for preventing or treating senile osteoporosis
  • Application of urolithin A in preparation of medicine for preventing or treating senile osteoporosis
  • Application of urolithin A in preparation of medicine for preventing or treating senile osteoporosis

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Embodiment Construction

[0030] The present invention will be further described below in conjunction with the accompanying drawings and specific embodiments.

[0031] 1. Materials and methods

[0032] 1. Materials

[0033] 1.1 Main drugs and reagents

[0034] Urolithin A (urolithin A, Uro-A) was purchased from Sigma, USA. Paraformaldehyde, sterile PBS, hematoxylin, eosin, decalcification solution, absolute ethanol, 4% chloral hydrate, etc.

[0035] 1.2 Main instruments

[0036] Axiovert 40C inverted microscope was purchased from Zeiss Company, Germany; Micro-CT was purchased from SkyScan 1176, Belgium; paraffin microtome was purchased from Leica 2135, Germany; broiler was purchased from Leica 1120, Germany.

[0037] 2. Experimental method

[0038] 2.1 Experimental animals: 28 healthy female SPF C57BL / J6 mice, 8 weeks old, provided by Animal Experiment Center of Soochow University.

[0039] 2.2 Grouping of experimental animals

[0040] The above-mentioned purchased animals were randomly divided in...

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Abstract

The invention relates to an application of urolithin A in preparation of a medicine for preventing or treating senile osteoporosis. According to the invention, Micro-CT and Hamp are adopted; e dyeing results prove that by oral administration of the urolithin A, the bone mass of senile osteoporosis mice can be improved, osteoblast proliferation and differentiation can be promoted, and irreversible bone loss caused by age factors can be inhibited. The senile osteoporosis is ubiquitous and inevitable in the elderly and is a systemic bone disease characterized by reduction of bone mass and bone tissue microstructure degeneration, and a Micro-CT result indicates that after the elderly C57 mouse takes urolithin A, the bone mass of the proximal femur, the bone mass of the vertebral column, the bone mass of the vertebral column and the bone mass of the bone mass of the spine of the elderly C57 mouse, and the bone mass of the bone mass of the bone mass of the elderly C57 mouse. And teeth and tibia bone masses are protected to different extents. Therefore, the urolithin A has a positive regulation effect on bone metabolism, can be used as an active component of the medicine for preventing or treating osteoporosis, especially senile osteoporosis, and provides a new solution thought for preventing and treating osteoporosis.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of urolithin A in the preparation of medicines for preventing or treating senile osteoporosis. Background technique [0002] Senile osteoporosis (SOP) is a common metabolic disease in orthopedics. In aging populations, it is manifested by progressively reduced trabecular volume and fragile skeletal architecture. Previous studies have shown that in many elderly individuals, age-induced osteoporosis usually leads to the disorder of bone microarchitecture, which eventually makes patients prone to osteoporotic fractures, which seriously affects the quality of life of patients. At present, the drug treatment plan for SOP is relatively complicated, such as estrogen replacement therapy, bisphosphonate (alendronate) and denosumab, etc. are often used clinically, but these applications still have certain effects after long-term treatment. side effects, such as increas...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P19/10
CPCA61K31/352A61P19/10
Inventor 耿德春陶华强柏家祥葛高然杨晨李文明肖龙徐耀增杨惠林
Owner THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIV