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Application of hsacirc0003045 as breast cancer diagnosis and/or prognosis marker

A prognostic marker, breast cancer technology, applied in the field of tumor markers, can solve problems such as the decline of 5-year survival rate, and achieve the effect of good detection specificity

Pending Publication Date: 2022-04-29
SHANDONG UNIV QILU HOSPITAL
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the 5-year survival rate for patients diagnosed with stage I breast cancer is 100%, the 5-year survival rate for patients diagnosed with stage IV breast cancer drops dramatically to 26%

Method used

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  • Application of hsacirc0003045 as breast cancer diagnosis and/or prognosis marker
  • Application of hsacirc0003045 as breast cancer diagnosis and/or prognosis marker
  • Application of hsacirc0003045 as breast cancer diagnosis and/or prognosis marker

Examples

Experimental program
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Embodiment 1

[0038] (1) Clinical samples

[0039] From June 27, 2016 to July 8, 2021, 163 breast cancer patients were recruited at Qilu Hospital of Shandong University. All patients and controls were Han females.

[0040] Cancer and paracancerous tissues of 163 breast cancer patients were collected, and fresh tissue samples were immediately stored in liquid nitrogen until further analysis. All breast cancer and adjacent tissues were obtained during surgery. All participants obtained written informed consent. This study was approved by the Ethics Committee of Qilu Hospital of Shandong University.

[0041] (2) RNA extraction (TRIZOL method)

[0042] 1) Take out 30-50 mg of tissue samples stored in liquid nitrogen and quickly transfer them to EP tubes, add 700 μl of Trizol reagent, and use tissue scissors to fully cut the tissue until it becomes a paste (no visible particles). Add 280ml of RNase-free ddH to the above lysate 2 O, mix upside down, let stand at room temperature for 5 minut...

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Abstract

The invention relates to an application of hsacirc0003045 as a breast cancer diagnosis and / or prognosis marker. The breast cancer forms an important threat to female health, the frequency of drug resistance, metastasis and relapse of the disease is high, the prognosis condition of advanced breast cancer patients is poor, and an early diagnosis marker is of great significance for avoiding poor prognosis of the breast cancer. The invention provides the application of the hsacirc0003045 as the breast cancer diagnosis and / or prognosis marker, the expression quantity of the marker in focus tissues and para-carcinoma tissues has obvious difference, and the marker is related to poor prognosis of the breast cancer and has important detection value for clinical diagnosis and poor prognosis prevention and treatment of the breast cancer.

Description

technical field [0001] The invention belongs to the technical field of tumor markers, and in particular relates to the application of hsa_circ_0003045 as a diagnostic and / or prognostic marker for breast cancer. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Breast cancer is one of the most common malignant tumors in women. The latest cancer statistics in the United States show that female breast cancer has surpassed lung cancer to become the most common malignant tumor. Although lung cancer is the leading cause of cancer death, the incidence and mortality of breast cancer remain high worldwide. Currently, neoadjuvant chemotherapy combined with local therapy (surgery or...

Claims

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Application Information

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IPC IPC(8): C12Q1/6886
CPCC12Q1/6886C12Q2600/178C12Q2600/118
Inventor 张凯王亚文陈燕朵徐瑶陈旭
Owner SHANDONG UNIV QILU HOSPITAL
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