Microneedle female die, microneedle female die, preparation process of microneedle female die, microneedle patch and preparation process of microneedle patch

A technology of microneedle and master mold, applied in the field of microneedle, can solve the problems of complex process, low production efficiency of negative mold, long time consumption, etc., and achieve the effect of simple operation

Active Publication Date: 2022-05-10
YOUWE ZHUHAI BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The process of this operation method is relatively complicated, takes a long time, and the production efficiency of the female mold is low, so it is difficult to reduce the production cost

Method used

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  • Microneedle female die, microneedle female die, preparation process of microneedle female die, microneedle patch and preparation process of microneedle patch
  • Microneedle female die, microneedle female die, preparation process of microneedle female die, microneedle patch and preparation process of microneedle patch
  • Microneedle female die, microneedle female die, preparation process of microneedle female die, microneedle patch and preparation process of microneedle patch

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] Embodiment 1 microneedle master mold

[0086] combine Figure 1-Figure 9 As shown, a microneedle master mold includes a mold core 100, a mold frame 200, a defoaming film 300 and a mold cover 400, wherein the mold core 100 and the mold frame 200 are combined to form the bottom mold 600 of the microneedle master mold, and the bottom mold The mold 600 is provided with a PDMS forming tank 500, and the defoaming film 300 is attached to the upper surface of the PDMS forming tank 500 for degassing operation; The defoaming film 300 is tightly pressed onto the PDMS forming groove 500, and the mold cover 400 is used for setting the female mold to ensure that the PDMS mixture will not be deformed during the forming process. The mold core 100 , the mold frame 200 and the mold cover 400 can be made of metal or 3D printing material, and the material of the defoaming film 300 can be made of PET material.

[0087] Specifically, see figure 2 As shown, the mold core 100 includes a fi...

Embodiment 2

[0103] Embodiment 2 microneedle negative mold and its preparation process

[0104] The embodiment of the present invention also provides a microneedle female mold. The microneedle female mold is a PDMS female mold with an inverted microneedle array inside. The microneedle female mold is prepared by using the microneedle female mold in Example 1. , and its preparation process is as follows:

[0105] Step 1. Weigh 10g of curing agent and 100g of uncrosslinked PDMS solution, keep mechanical stirring at 500rpm for 3min, place in a vacuum defoamer to remove air bubbles, and obtain PDMS mixed solution;

[0106] Step 2: Put the mold frame 200 on the mold core 100, and use bolts to fix the mold frame 200 to the bolt holes 170 and 250 of the mold core 100, and after fixing, a microneedle platform accommodation cavity 270 and the microneedle platform 110 form a A PDMS forming groove 500 is provided, the bottom of the PDMS forming groove 500 is the free end surface of the microneedle pl...

Embodiment 3

[0113] This embodiment 3 provides a microneedle master mold, including a bottom mold 600, a mold cover and a defoaming film 300. The difference from the embodiment 1 is that the bottom mold 600 described in this embodiment 3 has an integrated structure, see attached Figure 13 As shown, the integrally formed bottom mold 600 is provided with a PDMS forming groove 500, and the PDMS forming groove 500 in the bottom mold in the third embodiment is circular. The PDMS forming groove is recessed from the end surface of the bottom mold 600, and a microneedle protrusion 120 is arranged in the middle, and the shape of the microneedle protrusion 120 includes but not limited to bullet shape, conical shape, pyramid shape, okra shape and pyramid shape. The defoaming film 300 covers the PDMS molding tank 500 , and the mold cover (not shown) is pressed on the bottom mold 600 and the defoaming film 300 .

[0114] Further, the upper surface of the bottom mold 600 can also be provided with an o...

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Abstract

The invention belongs to the technical field of microneedles, and particularly discloses a microneedle female die, a female die, a preparation process of the female die, a microneedle patch and a preparation process of the microneedle patch. The microneedle female die comprises a PDMS forming groove and a defoaming film, and a plurality of microneedle protrusions are arranged in the PDMS forming groove in an array mode. And the defoaming film is attached to the upper part of the PDMS forming groove. When the female die is prepared from the female die, interference PDMS mixed liquid is added into the PDMS forming groove, the bubble removing film is attached to the upper portion of the PDMS forming groove to seal the PDMS mixed liquid in the PDMS forming groove, and bubble-free planar shaping treatment is conducted on the female die. The female die obtained by recarving the female die is good in integrity, and the polymer microneedle in any form can be prepared; the microneedle produced through the female die has the advantages of being accurate in drug delivery, controllable, stable, easy to produce, capable of saving materials and capable of being flexibly transformed, the yield and the preparation efficiency can be effectively improved, and the cost is reduced.

Description

technical field [0001] The invention belongs to the field of microneedle technology, and in particular relates to a microneedle master mold, a process for preparing a microneedle female mold by using the microneedle master mold, a microneedle patch prepared based on the microneedle female mold, and a preparation process thereof. Background technique [0002] Using mold casting method to prepare soluble microneedles is a common microneedle manufacturing method. In the prior art, a microneedle master mold is generally used to prepare a PDMS (polydimethylsiloxane polymer organosilicon compound) female mold, and then pass through the female mold. Prepare the microneedles. However, when the PDMS mixture is injected into the master mold after removing air bubbles, a large number of air bubbles will still be generated in the microneedle female mold when the mold cover is put on for shaping, which will affect the overall flatness of the soluble microneedle female mold silica gel pla...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B29C33/38B29C33/00B29C39/02A61M37/00
CPCB29C33/3842B29C33/0022B29C39/026A61M37/0015
Inventor 李成国冷钢马永浩杨健
Owner YOUWE ZHUHAI BIOTECH CO LTD
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