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Probucol dry emulsion composition as well as preparation method and application thereof

A technology of probucol and composition, applied in the field of probucol dry emulsion composition and preparation thereof, can solve problems such as long distance of clinical medication, reduce cardiovascular and cerebrovascular events, prevent and treat cardiovascular and cerebrovascular obstruction, and enhance anti-arterial Effects of atherosclerosis

Pending Publication Date: 2022-05-13
北京方同顺医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0029] Although all the above studies have been made into certain dosage forms, they are still far from clinical application

Method used

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  • Probucol dry emulsion composition as well as preparation method and application thereof
  • Probucol dry emulsion composition as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Embodiment 1: the preparation of probucol dry emulsion composition

[0059] 2.32g poloxamer 407, 0.464g gelatin, 0.139g polyoxyl (40) stearate, 6.032g probucol, operate according to the preparation method of the probucol dry emulsion composition, get probucol Dry emulsion composition, taking batch 20180107 as an example, the average particle size is 2.895 μm.

Embodiment 2

[0060] Embodiment 2: the preparation of probucol dry emulsion composition

[0061] 2.32g poloxamer 407, 0.464g gelatin, 0.139g polyoxyl (40) stearate, 6.032g probucol, 3.675g glyceryl monostearate, according to the probucol dry emulsion composition The preparation method is operated to obtain the probucol dry emulsion composition, taking batch 20171205 as an example, the average particle size is 3.72 μm.

Embodiment 3

[0062] Embodiment 3: the preparation of probucol dry emulsion composition

[0063] 2.32g poloxamer 407, 0.464g gelatin, 0.139g polyoxyl (40) stearate, 6.032g probucol, 7.35g glyceryl monostearate, according to the probucol dry emulsion composition The preparation method is operated to obtain the probucol dry emulsion composition, taking batch 20180111 as an example, the average particle size is 5.521 μm.

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Abstract

The invention belongs to the technical field of pharmaceutical preparations, and relates to a probucol dry emulsion composition as well as a preparation method and application thereof. The probucol dry emulsion composition provided by the invention consists of a hydrophilic emulsifier, a lipophilic emulsifier, a co-emulsifier, a freeze-drying protective agent and probucol, the total mass of the hydrophilic emulsifier accounts for 4.5%-5.3% of the total prescription dosage; the total mass of the lipophilic emulsifier accounts for 0-11.72% of the total prescription dosage; the total mass of the freeze drying protective agent accounts for 71.9%-83.8% of the total prescription dosage; the mass of the probucol accounts for 9.3%-10.9% of the total prescription dosage. According to the probucol dry emulsion composition obtained by the invention, an accelerated stability test lasts for 3 months, a sample is stable, the in-vivo bioavailability of a rat can reach up to 228.11% compared with that of a probucol tablet, and the effect of preventing and treating atherosclerosis of the rat is obviously enhanced compared with that of the probucol tablet.

Description

[0001] This application is a divisional application for an invention patent with an application date of June 12, 2019, an application number of 201910505066.9, and an invention title of "A Probucol Dry Emulsion Composition and Its Preparation Method and Pharmaceutical Application". technical field [0002] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a probucol dry emulsion composition and a preparation method and application thereof. Background technique [0003] In recent years, the incidence rate of acute myocardial infarction in my country is 5 / 10,000, and more than 1 million patients die from the disease every year; the incidence rate of cerebral infarction is 13 / 10,000, and the disability and mortality rate is 10 / 10,000 in cities. Around 1.5, in rural areas it is around 10 / 10,000. At present, the clinical methods for solving acute cardiovascular and cerebrovascular infarction include: drug thrombolysis, antico...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61K47/10A61K47/42A61K47/14A61K31/10A61P9/10
CPCA61K47/10A61K47/42A61K47/14A61K31/10A61P9/10A61K9/19
Inventor 方树清
Owner 北京方同顺医药科技有限公司
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