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Application of broadband strong-field pulse terahertz wave in promoting apoptosis of human breast cancer cells and inhibiting proliferation of human breast cancer cells

A breast cancer cell and field pulse technology, applied in the field of terahertz irradiation, can solve the problems of blank application of cancer cells, and achieve the effect of inhibiting the proliferation rate and increasing the apoptosis rate

Pending Publication Date: 2022-05-13
CHONGQING INST OF GREEN & INTELLIGENT TECH CHINESE ACADEMY OF SCI +1
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Problems solved by technology

[0004] Although terahertz technology has been studied for many years, its biomedical applications other than detection are still in its infancy, especially in cancer cells.

Method used

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  • Application of broadband strong-field pulse terahertz wave in promoting apoptosis of human breast cancer cells and inhibiting proliferation of human breast cancer cells
  • Application of broadband strong-field pulse terahertz wave in promoting apoptosis of human breast cancer cells and inhibiting proliferation of human breast cancer cells
  • Application of broadband strong-field pulse terahertz wave in promoting apoptosis of human breast cancer cells and inhibiting proliferation of human breast cancer cells

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Embodiment

[0020] Cell culture conditions: Human breast cancer cells (MCF-7, purchased from Wuhan Punuosheng Life Technology Co., Ltd., Cat. No. CL-0149) were cultured in 1640 basal medium (Gibco / Invitrogen), supplemented with 10% fetal bovine serum (Hyclone ), 10mM Hepes buffer, 100 units / mL penicillin and 100μg / mL streptomycin, and then 2×10 5 Cells / well were seeded in 24-well polystyrene tissue culture-treated plates, incubated overnight and exposed the next day.

[0021] Terahertz radiation / irradiation conditions: use a strong field broadband (≥10THz) pulsed THz source from a femtosecond laser system (12mJ, pulse width 40fs), adjustable repetition rate (1kHz, 100Hz, 10Hz and 1Hz) and plasma interaction. Human breast cancer cells were irradiated in medium in 24-well polystyrene tissue culture plates at room temperature (approximately 21°C). In all experiments, the same non-irradiated plates were used as controls. Cell viability and morphology were monitored by light microscopy (NOV...

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Abstract

The invention provides application of broadband high-field pulse terahertz waves in promoting apoptosis of human breast cancer cells and application of the broadband high-field pulse terahertz waves in inhibiting proliferation of the human breast cancer cells. The bandwidth of the high-field terahertz waves is larger than or equal to 10 THz. The irradiation conditions of the terahertz waves are as follows: the average power density is 4.8 mW / cm < 2 > to 179 mW / cm < 2 >, the repetition frequency is 100 Hz to 1 kHz, and the irradiation time is 2 to 4 hours. According to the method, the proliferation rate of human breast cancer cells exposed to broadband pulse terahertz radiation (the average power density is 17.89-179 mW / cm < 2 >, the repetition frequency is 100-1000 Hz, and the irradiation time is 3 hours) is remarkably inhibited, and the apoptosis rate is remarkably increased.

Description

technical field [0001] The invention belongs to the technical field of terahertz (THz) irradiation, and specifically relates to the application of broadband pulsed terahertz waves in promoting the apoptosis of human breast cancer cells and inhibiting the proliferation of human breast cancer cells. The bandwidth of the strong field terahertz waves is ≥ 10 THz . Background technique [0002] The terahertz region of the electromagnetic (EM) spectrum is defined as the frequency range from 0.1 to 10 THz (1 THz = 10 12 Hz) or wavelengths ranging from 30 to 3000 microns, between the microwave and infrared regions of the electromagnetic spectrum. The terahertz band can cover the characteristic spectra of semiconductors, plasmas, organisms and biomacromolecules. Terahertz technology can be widely used in radar, remote sensing, homeland security and anti-terrorism, highly confidential data communication and transmission, atmospheric and environmental monitoring, especially in real-t...

Claims

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Application Information

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IPC IPC(8): C12N13/00
CPCC12N13/00
Inventor 周欢彭晓昱
Owner CHONGQING INST OF GREEN & INTELLIGENT TECH CHINESE ACADEMY OF SCI
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