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Application of chlorsanguinarine in preparation of drugs or health care products for treating liver injury caused by arsenic

A technology for blood chlorination and liver damage, which is applied in the field of application of sanguinarine in the preparation of arsenic-induced liver damage drugs or health care products, and can solve the problems of undiscovered application and undiscovered sanguinarine

Pending Publication Date: 2022-05-24
THE KEY LAB OF CHEM FOR NATURAL PROD OF GUIZHOU PROVINCE & CHINESE ACADEMY OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, whether SC has a protective effect on mouse liver injury caused by sodium arsenite (SA) has not been reported yet.
In the prior art, no sanguinarine has the effect of preventing and treating liver damage caused by arsenic, nor has the application of the present invention in medicines and health products for preventing and treating liver damage caused by arsenic been found

Method used

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  • Application of chlorsanguinarine in preparation of drugs or health care products for treating liver injury caused by arsenic
  • Application of chlorsanguinarine in preparation of drugs or health care products for treating liver injury caused by arsenic
  • Application of chlorsanguinarine in preparation of drugs or health care products for treating liver injury caused by arsenic

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] 1. Experimental animals and materials

[0031] 1. Sanguinarine: In the technical scheme of the invention, sanguinarine, or SC, refers to the compound of the following structure:

[0032]

[0033] 2. Experimental animals: adult male Kunming mice, weighing 25-30 g, license number: SCXK (Liao) 2020-0001, grade SPF, provided by Liaoning Provincial Laboratory Animal Resource Center.

[0034] Experimental reagents: sodium arsenite was purchased from Sigma Company in the United States; alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were purchased from Redu Life Science Co., Ltd.; total bilirubin (TBIL ) assay kits were purchased from Changchun Huili Biotechnology Co., Ltd.; Malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GSH) assay kits were purchased from Nanjing Jiancheng Biotechnology Co., Ltd. Engineering Institute; hematoxylin-eosin (HE) dye solution was purchased from Wuhan Sewell Biotechnology Co., Ltd.; 4% parafor...

Embodiment 2

[0065] Taking sanguinarine chloride as the raw material drug, adding 1 / 12 of medicinal starch, and granulating to obtain granules.

Embodiment 3

[0067] Take sanguinarine chloride as a raw material drug, add 1 / 12 of medicinal starch, mix well, and put into capsules to obtain capsules.

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PUM

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Abstract

The invention relates to an application of sanguinarine in preparation of a medicament or a health care product for arsenic-induced liver injury, NaAsO2 is successfully utilized to induce mouse liver injury, and a research result shows that the sanguinarine obviously relieves the reduction of mouse body weight, SOD and GSH, and the increase of liver weight, alanine transaminase (ALT), aspartate transaminase (AST), total bile haematochrome (TBIL) and MDA caused by the NaAsO2, and can be used for preparing a medicament or a health care product for arsenic-induced liver injury. Results show that the sanguinarine has potential application value in the aspect of liver injury caused by NaAsO2, and the sanguinarine can be applied to preparation of drugs or health care products for preventing and treating liver injury caused by arsenic, especially the sanguinarine can be applied to preparation of drugs or health care products for preventing and treating liver injury caused by sodium arsenite.

Description

technical field [0001] The invention relates to the field of drug application, in particular to the application of sanguinarine chloride in the preparation of arsenic-induced liver injury drugs or health care products. Background technique [0002] As a naturally occurring environmental toxicant and carcinogen, arsenic can easily enter humans and animals through food, water, and occupational contamination, causing damage to multiple organ systems. As the main metabolism and detoxification organ of arsenic, the liver can be retained in high concentrations during its metabolism, resulting in liver diseases, such as abnormal liver function, hepatomegaly, liver fibrosis, liver cirrhosis and even cancer. One of the leading causes of arsenic death. Studies have found that oxidative stress and lipid peroxidation are the pathogenic factors of arsenic-induced liver damage. Arsenic can produce a large number of free radicals and non-free radical products in liver metabolism, causing ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4741A61P1/16A61P39/02
CPCA61K31/4741A61P1/16A61P39/02
Inventor 骆衡杨和平晏晨程莎
Owner THE KEY LAB OF CHEM FOR NATURAL PROD OF GUIZHOU PROVINCE & CHINESE ACADEMY OF SCI