Unlock instant, AI-driven research and patent intelligence for your innovation.

Anti-influenza virus pharmaceutical composition

A compound and dry suspension technology, applied in the field of pharmaceutical preparations, to achieve the effects of improving the operating environment, reducing the loss of raw materials and reducing production costs

Pending Publication Date: 2022-06-03
NANTONG NUOTAI BIOLOGICAL PHARMA CO LTD +1
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, at present, there is no research on the preparation of compound 1, and the development of a suitable pharmaceutical dosage form of compound 1 that can effectively improve the stability of the drug, meet the convenience of patients, and improve the compliance of patients will help compound 1 benefit patients as soon as possible. Meeting clinical unmet needs

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Anti-influenza virus pharmaceutical composition
  • Anti-influenza virus pharmaceutical composition
  • Anti-influenza virus pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1, the preparation of the oral dry suspension of compound I

[0031] The prescription contents are as follows:

[0032]

[0033]

[0034] Preparation method: First, after crushing the raw and auxiliary materials of the prescription amount respectively, pass through an 80-mesh sieve, and set aside; then mix the compound I of the recipe amount, 33.36% (w / w) sorbitol and xanthan gum evenly to obtain drug granules; then mix the remaining amount of sorbitol, titanium dioxide, orange flavor essence, and sodium saccharin evenly to obtain blank granules; mix the drug-containing granules, blank granules, and sodium benzoate according to the method of equal increments, and pass through a 60-mesh sieve; dry method After granulation, the granules were passed through a 18-mesh sieve for granulation, and then packaged to obtain an oral dry suspension containing Compound I. The content of Compound I was 3 mg / 100 mg.

[0035] Wherein the particle size of compound I D(...

Embodiment 2

[0036] Embodiment 2, the preparation of the oral dry suspension of compound I

[0037] prescription:

[0038]

[0039]

[0040] Preparation method: first, after pulverizing the raw and auxiliary materials of the prescription amount respectively, pass through an 80 mesh sieve, and set aside; then mix the compound I of the prescription amount, 33.40% (w / w) sorbitol and xanthan gum evenly to obtain Then mix the remaining amount of sorbitol, titanium dioxide, sodium dihydrogen citrate, orange flavor essence, and sodium saccharin evenly to obtain blank granules; mix the drug-containing granules, blank granules and sodium benzoate according to the method of equal increments, and pass 60-mesh sieve; after dry granulation, pass through a 18-mesh sieve for sizing, and pack separately to obtain a dry suspension containing Compound I, and the content of Compound I is 5 mg / 100 mg.

[0041] Wherein the particle size of compound I D(v,90)=35 μm.

Embodiment 3

[0042] Embodiment 3, the preparation of the oral dry suspension of compound I

[0043] The prescription contents are as follows:

[0044]

[0045]

[0046] Preparation method: First, after crushing the raw and auxiliary materials of the prescription amount respectively, pass through an 80-mesh sieve, and set aside; then mix the compound I of the recipe amount, 33.36% (w / w) sorbitol and xanthan gum evenly to obtain Then mix the remaining amount of sorbitol, titanium dioxide, sodium dihydrogen citrate, orange flavor essence, and sodium saccharin evenly to obtain blank granules; mix the drug-containing granules, blank granules and sodium benzoate according to the method of equal increments, and pass 60-mesh sieve; after dry granulation, pass through a 18-mesh sieve for sizing, and pack separately to obtain an oral dry suspension containing Compound I, and the content of Compound I is 3 mg / 100 mg.

[0047] Wherein the particle size of compound I D(v,90)=30 μm.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
Login to View More

Abstract

According to the dry suspension containing the novel anti-influenza medicine and the preparation method of the dry suspension, the dry suspension containing the compound I is good in stability, high in dissolution rate and good in taste, adults can take the dry suspension, meanwhile, children and old people can use the dry suspension conveniently, and the preparation method is easy to operate, suitable for industrial production and application and suitable for popularization and application. And the compound I dry suspension prepared by the method provided by the invention is good in medicine uniformity.

Description

technical field [0001] The application belongs to the technical field of pharmaceutical preparations, and in particular relates to an anti-influenza virus pharmaceutical composition, in particular to a pyrimidine derivative anti-influenza virus dry suspension. Background technique [0002] Influenza virus, namely influenza virus (IFV), is a segmented single-stranded antisense RNA virus that can cause influenza in humans and animals. The pandemic of influenza and human avian influenza has become a social issue of global concern and a major public health issue that threatens human health. According to estimates by the World Health Organization, seasonal influenza epidemics can cause 3 to 5 million severe cases and 250,000 to 500,000 deaths worldwide each year. my country is a place where influenza frequently occurs and is the area where influenza first strikes many times. The number of influenza cases is estimated to reach tens of millions of people every year. Influenza and...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K47/26A61K47/36A61K47/02A61K47/12A61K31/506A61P31/16
CPCA61K9/1617A61K9/1623A61K9/1652A61K9/1611A61K31/506A61P31/16
Inventor 徐安佗周宁张新
Owner NANTONG NUOTAI BIOLOGICAL PHARMA CO LTD