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Preparation method of salvianolic acid A

A salvianolic acid, high-content technology, applied in the field of preparation of salvianolic acid A, can solve the problems of increased separation difficulty, complicated use process, high cost, etc., and achieve the goals of shortened separation and purification time, reduced labor intensity, and improved yield Effect

Pending Publication Date: 2022-06-03
JIANGZI QINGFENG PHARMACEUTICALS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Existing a large number of patents and documents about the preparation method of salvianolic acid A, such as: 1) the preparation method of salvianolic acid A disclosed in CN101041620A, its salvianolic acid A is directly purified after being extracted from medicinal materials, and this method is due to The content of salvianolic acid A in medicinal materials is extremely low, the purity of the final product prepared by this method is low, and the production cost is high, and most of the extraction solvents are second-class solvents, which have potential safety hazards. The above factors are not conducive to industrial production and preparation
2) A preparation method of salvianolic acid A disclosed in CN103570548A, this process solves the problem of the source of salvianolic acid A, but since the extract is directly heated and reacted without alcohol precipitation, purification and impurity removal, there are the following unfavorable factors: Contains substances such as proteins, colloids and polysaccharides. Heating reaction will combine with salvianolic acid A, which will increase the difficulty of subsequent separation and reduce the service life of subsequent chromatographic fillers, thereby increasing production costs.
3) In a method for preparing salvianolic acid A disclosed in CN103242161A, no in-depth research has been done on the approach and conditions for the production of salvianolic acid A by heating reaction, and the final prepared salvianolic acid A has a purity of only 90%. Lower than the requirements for raw materials in the current new drug research process
The particle size is not uniform. Before use, it is necessary to filter out the fine powder and perform activation treatment to remove the residual impurities of the product itself. The use process is complicated, which is not conducive to industrial production.
[0005] In summary, in the prior art, although the extraction and yield of some salvianolic acid A have been improved to a certain extent, there are still difficulties in separation and purification, cumbersome operation and unfavorable industrialization / industrial production, high cost, and final The problem of low purity and content of finished products

Method used

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  • Preparation method of salvianolic acid A
  • Preparation method of salvianolic acid A
  • Preparation method of salvianolic acid A

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-4

[0056] Example 1-4: Dalicolic acid B water sedimentation

Embodiment 1

[0058] Take salvia herbs (drinking tablets, thick tablets), 4 parts, 100g per part, crushed, through a four-mesh sieve, soaked in water at temperature 78 °C± 2 °C three times (10 times, 8 times, 6 times), each time extracted for 1h. The extract was concentrated at 60 °C under reduced pressure to the relative density of the extract 1.15, combined with the concentrate, added 95% ethanol to adjust the ethanol concentration in the solution of 70%, 25 °C ± 2 °C at a stand alcohol deposition for 36h, filtered, the filtrate was concentrated at T≤65 °C (60 °C) under reduced pressure to the ethanol concentration in the solution ≤5% (4%), to obtain an alcohol deposition concentrate.

Embodiment 2

[0060] Take salvia herbs (short section), 4 parts, 100g per part, crushed, through a four-mesh sieve, soaked in water at temperature 75 °C± 2 °C for three times (10 times, 8 times, 6 times), each time extracted for 1.5h. The extract was concentrated at 50 °C under reduced pressure to the relative density of the extract 1.05, combined with the concentrate, added 90% ethanol to adjust the ethanol concentration in the solution of 75%, 35 °C ± 2 °C at 2 °C let stand for 24h, filtered, the filtrate was concentrated at T≤65 °C (50 °C) under reduced pressure to the ethanol concentration in the solution ≤5% (5%), to obtain an alcohol deposition concentrate.

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Abstract

The invention relates to a preparation method of salvianolic acid A. The preparation method comprises the following steps: purifying salvianolic acid A purified and extracted by medium and low pressure resin through normal-phase silica gel, crystallizing, extracting and freeze-drying. The method has the characteristics that the cost is low, the separation and purification are simple, the operation is easy, the industrial production is facilitated, and the high-content and high-purity salvianolic acid A is finally obtained.

Description

Technical field [0001] The present invention relates to the field of drug preparation, specifically to a method for preparing a danphenolic acid A. Background [0002] Salvianicacid A is a water-soluble phenolic acid compound contained in the medicinal herbs of salvia of the family Lipaceae, which has a very low content in medicinal materials and was first isolated from salvia in 1984 by Professor Li Lianniang (Li Lian-Niang, etal. Planta Medica,1984,50:227)。 Danphenolic acid A is one of the strongest known antioxidant compounds, and has extensive pharmacological activities in many aspects such as antioxidant, myocardial ischemia protection, antithrombosis, neuroprotective, anti-liver fibrosis, prevention and treatment of diabetes and other aspects (Du Guanhua, Qiu Yue, Zhang Juntian. Protective effect of danphenolic acid A on myocardial ischemia-reperfusion injury in rats[J].1995,(10):731;Ren Zihua. Research progress on the pharmacological effect of danphenolic acid A[J].Medical...

Claims

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Application Information

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IPC IPC(8): C07C67/58C07C67/56C07C67/52C07C69/732
CPCC07C67/58C07C67/56C07C67/52C07C69/732
Inventor 王章伟郭正友王振周鹏刘尧奇张毅刘艳红刘明颖黄冰峰蔡群芳
Owner JIANGZI QINGFENG PHARMACEUTICALS INC
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