Animal tissue sterile decellularization device

Abstract

The invention discloses an animal tissue sterile decellularization device, which relates to the technical field of tissue engineering, and is characterized in that the animal tissue sterile decellularization device comprises a tank body, a liquid outlet pipe is arranged at the bottom of the tank body, a liquid inlet pipe is arranged at the top of the tank body, and a supporting block is arranged at the bottom of the inner side of the tank body; a liquid accumulation channel for communicating the liquid outlet pipe with the interior of the tank body is formed in the bottom of the supporting block, a rotating motor is embedded in the top of the supporting block, and temperature control devices are embedded in the two opposite side walls of the decellularization liquid box body. According to the animal tissue sterile decellularization device, biological materials can be prevented from being wound into a whole, so that the decellularization treatment effect is improved; meanwhile, sterile treatment in the whole process can be guaranteed, the use of a sterilization technology can be effectively avoided or reduced, and the main components and key structures of the decellularized material are prevented from being damaged by adopting the sterilization technology; in addition, the device can provide an optimal temperature environment for the decellularization process by adjusting the temperature of the decellularization liquid.

Description

technical field [0001] The present invention relates to the technical field of tissue engineering, more particularly, it relates to an animal tissue aseptic decellularization device. Background technique [0002] With the development of economy and society, the application of biomaterials in medicine has become more and more prominent. Biomaterials refer to materials formed through biological processes, including cells and extracellular matrix. When biological materials are used in clinical practice, the biological materials need to be cleaned, sterilized, and decellularized. [0003] In the prior art, the biological material and the decellularization reagent are usually decellularized by shaking, and the biological material usually needs to be pretreated to remove excess tissue, and then the pretreated biological material is placed in a large reaction tank for shaking. Decellularization, as the oscillation progresses, the biological materials are easy to agglomerate and en...

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Problems solved by technology

[0003] In the prior art, the decellularization of biological materials and decellularization reagents is usually carried out by shaking, usually the biological materials need to be pretreated to remove excess tissue, and then the pretreated biological materials are placed in a large reaction tank for shaking Decellularization, as the oscillation proceeds, the biological materials are easy to agglomerate and entangled, which is not conducive to the decellularization of the biological materials and the reaction tank. Moreover, after the decellularization is completed, the biological materials need to be separated, which strengthens the follow-up process. Labor intensity, therefore, in order to improve the decellularization effect and reduce the subsequent processing, the biological material is usually decellularized in a small number of times, but this limits the batch size of the biological material

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