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Iron protein succinate oral liquid and preparation method thereof

A technology of iron protein succinate and iron oral liquid, applied in the field of iron protein succinate oral liquid and its preparation, can solve the problem of too fast iron release speed and the like, and achieve the advantages of slow iron release speed, improving stability and relieving the problem of constipation. Effect

Pending Publication Date: 2022-06-17
WUHAN CONFORM PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the iron release rate of the above-mentioned types of iron protein succinate is still too fast, which cannot solve the problem of constipation that is prone to occur when taking it

Method used

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  • Iron protein succinate oral liquid and preparation method thereof
  • Iron protein succinate oral liquid and preparation method thereof
  • Iron protein succinate oral liquid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The ferric protein succinate oral liquid provided in this example includes, in parts by weight, 5.5 g of ferric protein succinate, 5.5 g of admixture, 0.3 g of essence, 1.1 g of sodium bicarbonate, and lactic acid is added to adjust the pH value to about 7.8, and Water was added to adjust the concentration of iron protein succinate to 0.055g / mL; the admixtures were lactose and sorbitol of the same mass, both 2.75g.

[0025] The preparation method of the ferric protein succinate oral liquid provided by the present embodiment is:

[0026] S1. Weigh each raw material by portion, add admixture and sodium bicarbonate to water at 50°C and stir to dissolve;

[0027] S2. Add ferric protein succinate and stir to dissolve. After the solution is cooled, add essence, lactic acid and remaining water and stir evenly, so that the pH value is about 7.8, and the concentration of ferric protein succinate is 0.055g / mL to obtain protein succinic acid. Finished iron oral liquid.

Embodiment 2

[0029] The ferric protein succinate oral liquid provided in this example includes 6 g of ferric protein succinate, 4.6 g of admixtures, 0.3 g of essence, 0.8 g of sodium bicarbonate, lactic acid is added to adjust the pH value to about 7.8, and water is added. The concentration of ferric protein succinate was adjusted to 0.055g / mL; the admixtures were lactose and sorbitol of the same mass, both 2.3g.

[0030] The preparation method of the ferric protein succinate oral liquid provided in this example is the same as that in Example 1.

Embodiment 3

[0032] The ferric protein succinate oral liquid provided in this example comprises, in parts by weight, 5 g of ferric protein succinate, 6.2 g of admixture, 0.3 g of essence, 1.5 g of sodium bicarbonate, lactic acid is added to adjust the pH value to about 7.8, and water is added. The concentration of ferric protein succinate was adjusted to 0.055g / mL; the admixtures were lactose and sorbitol of the same mass, both 3.1g.

[0033] The preparation method of the ferric protein succinate oral liquid provided in this example is the same as that in Example 1.

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Abstract

The invention discloses iron protein succinylate oral liquid which comprises the following components in parts by weight: 5-6 parts of iron protein succinylate, 4.6-6.2 parts of an additive, 0.1-0.5 part of essence and 0.8-1.5 parts of sodium bicarbonate, and lactic acid and water are also added to regulate the pH value and the concentration of the iron protein succinylate. The additive is prepared from lactose, sorbitol and / or xylitol. The oral liquid is prepared by the following steps: dissolving the additive and the sodium bicarbonate in water at 40-50 DEG C; and adding the iron proteinsuccinylate to dissolve, cooling, adding the essence and the residual water, uniformly stirring, and adjusting the pH value to 7-7.8 and the concentration of the iron proteinsuccinylate to 0.045-0.055 g / mL to obtain the iron proteinsuccinylate oral liquid. In the oral liquid prepared by the invention, the molecular weight range of the iron protein succinate is 3000-5000 kDa, the iron loading amount is 2-3%, the iron release speed is slow, and the problem of constipation after a patient takes the iron protein succinate oral liquid in the past is effectively relieved by matching with the additive.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to a ferric protein succinate oral liquid and a preparation method thereof. Background technique [0002] Iron protein succinate is a new type of iron supplement for the treatment of iron deficiency anemia (IDA), which is acylated with casein anhydride and then chelated with ferric salts (such as FeCl3). Absolute and relative iron-deficiency anemia, latent or dominant iron-deficiency anemia due to insufficient intake or malabsorption of iron, acute or chronic blood loss, and infection in patients of all ages, anemia during pregnancy and lactation. There are few advantages such as gastrointestinal adverse reactions. At present, the dosage form sold on the domestic and foreign markets is mainly ferric protein succinate oral solution. Because of its unique properties, ferric protein succinate is protected by the protein membrane from being destroyed by gastric acid and enzymatically...

Claims

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Application Information

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IPC IPC(8): A61K38/17A61K9/08A61K47/26A61P7/06
CPCA61K38/1709A61K9/0095A61K47/26A61P7/06
Inventor 周小顺牟东升童国富贺容丽李进刘文双
Owner WUHAN CONFORM PHARMA CO LTD