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New medicinal application of naphazoline hydrochloride

A naphazoline and pharmacy technology, which is applied in the field of new drug use of naphazoline hydrochloride, and can solve the problems of no naphazoline hydrochloride, etc.

Pending Publication Date: 2022-06-24
SYNOGENBIOPHARMACO LTD NANJING CHINA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no relevant report on the induction of endogenous cardiomyocyte proliferation by naphazoline hydrochloride

Method used

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  • New medicinal application of naphazoline hydrochloride
  • New medicinal application of naphazoline hydrochloride

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1. In vitro test that Naphazoline Hcl promotes the proliferation of rat cardiomyocytes

[0033] (1) Culture of cardiomyocytes of SD rats

[0034] Cardiomyocytes of SD rats on day 3 were isolated and cultured in DMEM high-glucose medium (Hyclone) + 5% horse serum (GIBCO) in a 37°C, 5% carbon dioxide incubator.

[0035] (2) Experiment grouping and processing

[0036] Cardiomyocytes were isolated from SD rats, added with 5% horse serum (GIBCO) + DMEM high glucose medium (Hyclone), and treated with cytarabine (final concentration 20umol / L) to inhibit the growth of non-cardiomyocytes. After 48 hours of adhering to the wall, they were infected with cTnT-mAG-hGeminin (1 / 110) virus (MOI value of virus infection = 100), and after another 24 hours, they were replaced with DMEM medium containing 0.5% FBS, and grouped by drug treatment. The groups are as follows:

[0037] a. Experimental group: Naphazoline hydrochloride was added for treatment (the final concentration in ...

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PUM

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Abstract

The invention discloses a medicinal application of naphazoline. The application refers to application of naphazoline or pharmaceutically acceptable salts thereof in preparation of drugs for promoting myocardial cell proliferation. Experiments prove that naphazoline can promote myocardial cell proliferation of rats. Therefore, naphazoline can be used in the related fields of preparation of drugs for promoting myocardial cell proliferation and drugs for treating or preventing heart diseases, and provides a new drug and treatment thought for treating or preventing heart diseases such as myocardial infarction.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a new medicinal use of naphazoline hydrochloride. Background technique [0002] At present, cardiovascular disease has become the number one killer that threatens human health. There are 40 million heart failure patients worldwide, and it has become the main cause of human death. Studies have found that mammalian cardiomyocytes gradually lose their ability to proliferate in adulthood. Once myocardial infarction occurs, the loss of cardiomyocytes will be irreversible. There are about 2-4 billion cardiomyocytes in adults, and about 25% of the cardiomyocytes will be lost within a few hours after myocardial infarction. The remaining cardiomyocytes have very limited proliferative capacity and are not enough to restore the systolic function of the heart. The patient eventually suffers from heart failure. die. In order to solve this problem, in addition to surgical operations, basi...

Claims

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Application Information

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IPC IPC(8): A61K31/4174A61P9/04A61P9/10C12N5/077
CPCA61K31/4174A61P9/04A61P9/10C12N5/0657C12N2501/81
Inventor 卜晔杜建勇郑丽霞吴青朱小君熊敬维
Owner SYNOGENBIOPHARMACO LTD NANJING CHINA
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