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Efficient wet mixing granulator based on forward and reverse rotation

A two-way rotation, wet mixing technology, applied in the direction of mixers, mixer accessories, chemical instruments and methods, etc., can solve the problems of low mixing efficiency, uneven mixing, lack of sieving of particles, etc., to improve mixing efficiency and material mixing Uniform, quality-assured results

Pending Publication Date: 2022-06-24
ZHUHAI TONGYUAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Wet granulation is a method in which a binder is added to the drug powder, and the powder is agglomerated together by the bridging or bonding effect of the binder to prepare granules. It includes extrusion granulation, rotational granulation, fluidized granulation and stirring granulation. Granules, etc., the granules made by wet method are wetted on the surface, and have the advantages of good granule quality, beautiful appearance, strong wear resistance, good compression molding, etc., and are most widely used in the pharmaceutical industry. Among the existing technologies: authorized announcement The patent of No. CN 206415073 U discloses a high-efficiency wet mixing granulator, including a base, a material tank, a stirring mechanism and a granulation mechanism, the material tank is provided with a cylinder cover, and the cylinder cover is provided with a feed A bucket and a liquid inlet device, the stirring mechanism includes a stirring paddle arranged at the bottom of the material tank and a stirring drive mechanism for driving the rotation of the stirring paddle, and the granulation mechanism includes a paddle arranged on one side of the material tank The granulation knife and the granulation motor used to drive the granulation knife to rotate, but this high-efficiency wet mixing granulator has a single mixing method when used, the mixing efficiency is low, and the mixing is not uniform enough, and the granules after granulation are lacking. Screening leads to poor overall quality in the follow-up. For this reason, we propose a high-efficiency wet mixing granulator based on positive and negative bidirectional rotation

Method used

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  • Efficient wet mixing granulator based on forward and reverse rotation
  • Efficient wet mixing granulator based on forward and reverse rotation
  • Efficient wet mixing granulator based on forward and reverse rotation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1: a high-efficiency wet mixing granulator based on forward and reverse bidirectional rotation, including a base 1 and a discharge pipe 11;

[0027] Base 1: the middle of its upper surface is provided with a mixing barrel 4, the upper opening of the mixing barrel 4 is provided with a barrel cover 5, the edge of the barrel cover 5 is provided with a first hopper 6 and a second hopper 7 respectively, The installation port is provided with a spray pipe 8, the lower end of the spray pipe 8 is provided with a spray head, the bottom of the right end of the outer side of the mixing barrel 4 is installed with a granulating motor 9 through a flange, and the output shaft of the granulating motor 9 passes through the right side of the mixing barrel 4. The through hole at the lower end of the side is provided with a granulating blade 10 at the end, and a stirring mechanism 2 is provided inside the stirring barrel 4;

[0028] Discharge pipe 11: set at the discharge port a...

Embodiment 2

[0031] The difference between this embodiment and the first embodiment is that:

[0032] In this embodiment, the stirring mechanism 2 includes a sleeve 23 and a stirring blade 26 , the sleeve 23 is rotatably connected to the circular hole at the center of the bottom surface of the stirring barrel 4 through a sealed bearing, and the lower end of the outer side surface of the sleeve 23 is evenly provided with stirring blades 26 , the stirring blades 26 are all located at the inner bottom end of the mixing barrel 4, the inner lower end of the sleeve 23 is rotatably connected with the drive rod 25, the inner upper end of the sleeve 23 is movably inserted with a T-shaped frame 21, and the center of the bottom surface of the T-shaped frame 21 is connected. A square insertion rod 24 is provided, the square insertion rod 24 is inserted into the jack on the upper end of the driving rod 25, the upper end of the T-shaped frame 21 is evenly provided with a stirring rod 22, and the upper en...

Embodiment 3

[0035] The difference between this embodiment and the first embodiment is that:

[0036]In this embodiment, the blanking mechanism 3 includes a sliding plate 31, a vibration motor 32 and a spring 33, the left end of the sliding plate 31 is rotatably connected to the inner left end of the base 1, and the left end of the lower surface of the sliding plate 31 is evenly provided with filter holes , the right side of the base 1 is provided with an opening corresponding to the sliding material plate 31, and the convex strip arranged on the right end of the lower surface of the sliding material plate 31 is fixedly connected with the inner bottom wall of the base 1 through the evenly arranged springs 33. The vibration motor 32 is evenly arranged, the input end of the vibration motor 32 is electrically connected to the output end of the control switch group 15, the lower surface of the sliding plate 31 is provided with a guide plate 14 corresponding to the filter hole, and the left side...

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Abstract

The invention discloses an efficient wet mixing granulator based on forward and reverse bidirectional rotation. The efficient wet mixing granulator comprises a base and a discharge pipe, a stirring barrel is arranged in the middle of the upper surface of the base, a barrel cover is arranged at an opening in the upper end of the stirring barrel, a first hopper and a second hopper are arranged on the edge of the barrel cover, a granulation motor is installed at the bottom of the right end of the outer side face of the stirring barrel through a flange, and an output shaft of the granulation motor penetrates through a through hole in the lower end of the right side of the stirring barrel and is provided with a granulation blade at the end. A stirring mechanism is arranged in the stirring barrel; the discharging pipe is arranged at a discharging port in the bottom of the left end of the outer side face of the stirring barrel, and the interior of the discharging pipe is slidably connected with a baffle corresponding to the discharging port. According to the efficient wet mixing granulator based on forward and reverse rotation, materials can be rapidly mixed through forward and reverse rotation, mixing is more uniform and thorough, particles can be screened after granulation, and the practicability is high. And the quality of particles is greatly improved.

Description

technical field [0001] The invention relates to the technical field of high-efficiency wet mixing and granulation, in particular to a high-efficiency wet mixing granulator based on forward and reverse bidirectional rotation. Background technique [0002] Wet granulation is a method of preparing granules by adding a binder to the drug powder and coalescing the powder together by the bridge or bonding of the binder. It includes extrusion granulation, rotary granulation, fluidized granulation and stirring granulation. Granules, etc., the granules made by the wet method have the advantages of good particle quality, beautiful appearance, strong wear resistance, and good compression formability after the surface is wetted. They are the most widely used in the pharmaceutical industry. In the prior art: authorized publication Patent No. CN 206415073 U discloses a high-efficiency wet mixing granulator, including a base, a material tank, a stirring mechanism and a granulation mechanis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J2/10B01F33/80B01F33/83B01F35/11B01F35/30B01F35/33B02C18/14B02C23/16B07B1/28
CPCB01J2/10B02C18/14B02C23/16B07B1/28B02C2023/165
Inventor 黄毅陈敏陈戟易纯
Owner ZHUHAI TONGYUAN PHARMA CO LTD