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Application of melatonin derivative in prevention and treatment of plant fungal diseases

A plant fungal disease, melatonin technology, applied in the field of pesticides to achieve the effects of environmental friendliness, strong inhibitory activity, and easy synthesis

Active Publication Date: 2022-07-01
HUAZHONG AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, melatonin itself only has many reports on anti-biotic stress and combination with other drugs, and there are few reports on anti-fungal aspects.

Method used

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  • Application of melatonin derivative in prevention and treatment of plant fungal diseases
  • Application of melatonin derivative in prevention and treatment of plant fungal diseases
  • Application of melatonin derivative in prevention and treatment of plant fungal diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] Example 1: Synthesis of 5-methoxytryptamine:

[0060]

[0061] Step a, Synthesis of Intermediate II 5-methoxyindole-3-carbaldehyde: at N 2 Under the protection of the atmosphere, commercially available 5-methoxyindole (1.47g, 10mmol) was placed in a three-necked flask, and phosphorus oxychloride (2.5mL, 25.6mmol) was added dropwise to the system at 0°C, and added at 0°C. The reaction was continued for 2h at ℃. After the reaction of the raw materials was monitored by TCL, water was added to the system to quench the unreacted phosphorus oxychloride, and extracted with ethyl acetate (3*30 mL). The organic phases were combined and dried with anhydrous sodium sulfate, and concentrated under reduced pressure. Intermediate II was obtained as a pale yellow solid, yield: 98%.

[0062] Step b, Synthesis of Intermediate III(E)-5-methoxy-3-(2-nitrovinyl)-1H-indole: at N 2 Under the protection of atmosphere, intermediate II 5-methoxyindole-3-carbaldehyde (1.75g, 10mmol) and am...

Embodiment 2

[0064] Example 2: Synthesis of 5-trifluoromethyltryptamine:

[0065]

[0066] Step a, Synthesis of Intermediate II 5-methoxyindole-3-carbaldehyde: at N 2 Under the protection of the atmosphere, commercially available 5-methoxyindole (1.47g, 10mmol) was placed in a three-necked flask, and phosphorus oxychloride (2.5mL, 25.6mmol) was added dropwise to the system at 0°C, and added at 0°C. The reaction was continued for 2h at ℃. After the reaction of the raw materials was monitored by TCL, water was added to the system to quench the unreacted phosphorus oxychloride, and extracted with ethyl acetate (3*30 mL). The organic phases were combined and dried with anhydrous sodium sulfate, and concentrated under reduced pressure. Intermediate II was obtained as a pale yellow solid, yield: 98%.

[0067] Step b, Synthesis of Intermediate III(E)-5-methoxy-3-(2-nitrovinyl)-1H-indole: at N 2 Under the protection of atmosphere, intermediate II 5-methoxyindole-3-carbaldehyde (1.75g, 10mmol...

Embodiment 3

[0069] Example 3: Synthesis of 5,6-dichloro-1H-indol-3-yl)ethyl

[0070]

[0071] The synthetic steps of 5,6-dichloro-1H-indol-3-yl)ethyl refer to the general synthetic steps in Example 2, and the 5-trifluoromethylindole in Example 2 is replaced by 5.6-difluoromethyl indole Chlorindole.

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Abstract

The invention discloses application of a melatonin derivative to prevention and treatment of plant fungal diseases, and belongs to the field of pesticides. According to the present invention, the compound has characteristics of strong inhibition activity on the pathogenicity of Magnaporthe oryzae, good broad spectrum, and good inhibition effect on Fusarium graminearum, Botrytis cinerea, Sclerotinia sclerotiorum, Pestalotiopsis, Monilinia fruticosa, Bipolaris maydis, and Rhizoctonia solani, and is the potential broad spectrum pesticide antibacterial molecule, and can be used for the preparation of the antibacterial agent, such that the antibacterial agent can be used for the preparation of the antibacterial agent, and can be used for the preparation of the antibacterial agent, such that the antibacterial agent can be used for the preparation of the antibacterial agent, and the antibacterial agent can be used for the preparation of the antibacterial agent, and can be used for the preparation of the antibacterial agent, and can be used for the preparation of the antibacterial agent.

Description

technical field [0001] The invention belongs to the field of pesticides, and in particular relates to the use of a melatonin derivative in preventing and treating plant fungal diseases. Background technique [0002] With the increasing population, people's demand for food is also increasing; however, fungal diseases have seriously affected food production, and it is estimated that the loss of rice due to rice blast will reach 60 million mu in 2022. The effective methods to prevent plant fungal diseases mainly include biological control, the application of chemical pesticides and the improvement of crop resistance. However, the application of chemical pesticides is widely used because of its convenience and timeliness. However, the large-scale use of chemical pesticides will cause pesticide residues, affect human health and produce pesticide resistance. This requires researchers to continuously develop high-efficiency, environment-friendly, and non-cross-resistant pesticide...

Claims

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Application Information

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IPC IPC(8): A01N43/38A01N47/12A01N47/04A01P3/00C07D209/14
CPCA01N43/38A01N47/12A01N47/04C07D209/14
Inventor 滕怀龙李国田蔡寰宇李任建陈禹李俊翟倩倩
Owner HUAZHONG AGRI UNIV
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